REPRODUCIBILITY OF MUNIX IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
REPRODUCIBILITY OF MUNIX IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS
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DOI：
10.1002/mus.22204
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发表时间：
2011-12-01
期刊：
影响因子：
3.4
通讯作者：
Stalberg, Erik V.
中科院分区：
文献类型：
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作者：
Nandedkar, Sanjeev D.;Barkhaus, Paul E.;Stalberg, Erik V.
在这项研究中，我们研究了肌萎缩性侧索硬化症（ALS）患者运动单位数指数（MUNIX）的可重复性。方法：记录ALS患者的MUNIX。研究进行了18大鱼际和18鱼际下肌肉由两名操作员。采用单项研究的平均munx值、线性回归、相关系数和变异系数（COV）评估再现性。结果：平均值无显著性差异。线性回归显示相关性强。大多数患者为低冠状病毒。当MUNIX非常低时，出现高冠状病毒。COV在鱼际肌肉中高于鱼际下肌肉。结论：MUNIX在ALS患者中具有很好的重复性。当MUNIX很低时，COV可能会放大操作员间的变异。大鱼际肌的高变异性也是由于复合肌肉动作电位振幅的变异性。尽管两种肌肉都表现出良好的可重复性，但鱼际下更适合于个体患者的系列研究。肌肉神经44:919-922,2011
Introduction: In this study we investigated the reproducibility of motor unit number index (MUNIX) in patients with amyotrophic lateral sclerosis (ALS). Methods: MUNIX was recorded in patients with ALS. Studies were performed in 18 thenar and 18 hypothenar muscles by two operators. The reproducibility was assessed using mean MUNIX values, linear regression, correlation coefficient, and coefficient of variation (COV) in individual studies. Results: The mean values showed no significant difference. The linear regression showed a strong correlation. Most patients had low COV. A high COV was seen when MUNIX was very low. The COV was higher in thenar than in hypothenar muscles. Conclusions: MUNIX has very good reproducibility in ALS patients. COV may exaggerate interoperator variation when MUNIX is very low. The higher variability in the thenar muscle is also due to variability in compound muscle action potential amplitude. Although both muscles show good reproducibility, the hypothenar is better suited for serial studies in individual patients Muscle Nerve 44: 919-922, 2011