Body-water compartments measured by bio-electrical impedance spectroscopy in patients with chronic obstructive pulmonary disease
Body-water compartments measured by bio-electrical impedance spectroscopy in patients with chronic obstructive pulmonary disease
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DOI：
10.1016/s0261-5614(98)80038-1
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发表时间：
1998-02-01
影响因子：
6.3
通讯作者：
Schols, AMWJ
中科院分区：
文献类型：
--
作者：
Baarends, EM;Lichtenbelt, WDV;Schols, AMWJ
先前已证明，50 kHz下的单频生物电阻抗（BIA）测量是评估慢性阻塞性肺疾病（COPD）患者体内总水分（TBW）的有用方法。本研究采用氘和溴稀释法测定TBW和ECW（校正溴间隙），探讨生物电阻抗谱（BIS）是否能预测细胞外水（ECW），并改善对TBW的预测。在37名COPD患者中，使用BIS（5-500 kHz）测量获得预测方程，并在第二组40名COPD患者中进行交叉验证。BIS预测的TBW与实际TBW无显著性差异，且与健康受试者的标准估计误差（SEE）相当（男性相关系数：r = 0.88，SEE：2.3 L，女性r = 0.85，SEE：2.9 L）。使用BIS测量预测的ECW与测量的ECW无显著差异（男性r = 0.75，SEE：1.4 L，女性r = 0.73，SEE：1.2 L），但与大多数健康受试者研究相比，预测误差相对较大，预测和实际ECW之间的相关性相对较低。使用BIS预测的TBW与实际TBW相当，但使用50 kHz的BIA和患者特异性回归方程对TBW的预测没有改善。BIS预测ECW的误差限制了预测临床稳定型COPD个体患者液体转移的能力。
It was previously demonstrated that single frequency bio-electrical impedance (BIA) measurement at 50 kHz is a useful method to assess total body water (TBW) in patients with chronic obstructive pulmonary disease (COPD). In the present study it was examined whether bio-electrical impedance spectroscopy (BIS) could predict extracellular water (ECW) and improve the prediction of TBW in these patients.TBW and ECW (corrected bromide space) were measured by deuterium and bromide dilution. In 37 COPD patients prediction equations were obtained using BIS (5-500 kHz) measurements, and these were cross validated in a second group of 40 COPD patients. All patients were in a clinically stable condition.TBW predicted by BIS was not significantly different from actual TBW and demonstrated a comparable standard error of estimate (SEE) as found previously in healthy subjects (male correlation coefficient: r = 0.88, SEE: 2.3 L, female r = 0.85, SEE: 2.9 L). Predicted ECW using BIS-measurements was not significantly different from measured ECW (male r = 0.75, SEE: 1.4 L, female r = 0.73, SEE: 1.2 L), but the error in the prediction was relatively large and the correlation between predicted and actual ECW relatively low compared to most studies in healthy subjects.Predicted TBW using BIS was comparable to actual TBW, but presented no improvement of the prediction of TBW using BIA at 50 kHz and a patient specific regression equation. The error of the prediction of ECW by BIS limits the ability to predict fluid shifts in individual patients with clinically stable COPD.