Developmental Plasticity of Patterned and Regenerating Oral Organs.
Developmental Plasticity of Patterned and Regenerating Oral Organs.
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DOI：
10.1016/bs.ctdb.2015.07.005
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发表时间：
2015
影响因子：
--
通讯作者：
Fowler TE
中科院分区：
文献类型：
--
作者：
Streelman JT;Bloomquist RF;Fowler TE
在许多水生脊椎动物中，包括骨性和软骨性鱼类，牙齿和味蕾共同位于颌骨上。在这些动物中，味蕾在一生中不断更新，而牙齿则通过各种方式循环地更换整个器官。最近，对慈鲷鱼的研究对这些牙齿和感觉口腔器官的发育和再生有了新的认识。牙齿和味蕾密度在不同摄食策略的物种之间呈正相关变化，由基因组的共同区域和综合分子信号控制。发育中的牙齿和味蕾在早期模式阶段共享一个双能上皮，从那里指定了牙齿和味觉场。此外，这些器官共享一个共同的上皮带，在再生后期支持标签保留细胞。在形成和再生阶段，牙器官可以通过操纵BMP信号转变为味蕾命运。这些观察结果突出了牙齿和感觉器官类型之间令人惊讶的长期可塑性。在这里，我们回顾了这些发现，并讨论了跨越颅面器官模式和再生连续体的发育可塑性的含义。
In many aquatic vertebrates, including bony and cartilaginous fishes, teeth and taste buds co-localize on jaw elements. In these animals, taste buds are renewed continuously throughout life, whereas teeth undergo cycled whole organ replacement by various means. Recently, studies of cichlid fishes have yielded new insights into the development and regeneration of these dental and sensory oral organs. Tooth and taste bud densities co-vary positively across species with different feeding strategies, controlled by common regions of the genome and integrated molecular signals. Developing teeth and taste buds share a bipotent epithelium during early patterning stages, from which dental and taste fields are specified. Moreover, these organs share a common epithelial ribbon that supports label-retaining cells during later stages of regeneration. During both patterning and regeneration stages, dental organs can be converted to taste bud fate by manipulation of BMP signaling. These observations highlight a surprising long-term plasticity between dental and sensory organ types. Here, we review these findings and discuss the implications of developmental plasticity that spans the continuum of craniofacial organ patterning and regeneration.