Optic disc evaluation by optical coherence tomography in nonarteritic anterior ischemic optic neuropathy
Optic disc evaluation by optical coherence tomography in nonarteritic anterior ischemic optic neuropathy
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DOI：
10.1167/iovs.07-0171
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发表时间：
2007-09-01
影响因子：
4.4
通讯作者：
Munoz-Negrete, Francisco J.
中科院分区：
文献类型：
--
作者：
Contreras, Ines;Rebolleda, Gema;Munoz-Negrete, Francisco J.
目的。描述非动脉炎性前部缺血性视神经病变（NAION）患者视神经乳头（ONH）的特征，并使用光学相干断层扫描（OCT）将其与对照受试者进行比较。方法。 NAION 患者接受了完整的眼科检查，包括诊断时对 ONH 进行 OCT 扫描。 1.5、3、6个月后重复检查。年龄和性别匹配、没有眼部疾病的对照受试者也接受了类似的评估。数据是通过使用 StratusOCT（Carl Zeiss Meditec，都柏林，加利福尼亚州）的 ONH 分析协议获得的。结果。包括 23 名患者和 23 名对照受试者。在患有 NAION 的眼睛中，从急性期到 6 个月就诊期间，垂直积分边缘面积显着下降（P < 0.01）。从急性检查到 3 个月就诊，杯与椎间盘 (C/D) 面积比显着增加 (P = 0.002)。通过裂隙灯眼底镜检查评估，NAION 对侧眼与对照眼之间的 C/D 比（P < 0.001）和 C/D 面积比（P = 0.001）存在显着差异。 NAION 对侧眼的垂直积分边缘面积显着大于对照眼（P = 0.001）。对照眼、NAION 受影响眼和 NAION 对侧眼的视盘面积或垂直盘直径没有显着差异。结论。尽管 NAION 患者的 C/D 比值低于正常人群，并且神经纤维拥挤程度较高，但 NAION 患者和对照受试者之间的视盘大小没有差异。 NAION开发后，47.8%的眼睛的C/D比与对侧眼的差异超过0.1。
PURPOSE. To describe the characteristics of the optic nerve head (ONH) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and compare them with control subjects by using optical coherence tomography (OCT).METHODS. Patients with NAION underwent a complete ophthalmic examination, including OCT scanning of the ONH at diagnosis. The examination was repeated 1.5, 3, and 6 months later. Age- and sex-matched control subjects with no ocular disease underwent a similar evaluation. Data were obtained by using the ONH analysis protocol of the StratusOCT (Carl Zeiss Meditec, Dublin, CA).RESULTS. Twenty-three patients and 23 control subjects were included. In eyes with NAION, the vertical integrated rim area decreased significantly ( P < 0.01) from the acute phase to the 6-month visit. The cup-to-disc (C/D) area ratio increased significantly ( P = 0.002) from the acute examination to the 3-month visit. There was a significant difference between the NAION fellow eyes and the control eyes in C/D ratio, evaluated by slit lamp funduscopy ( P < 0.001), and in the C/D area ratio ( P = 0.001). The vertical integrated rim area was significantly ( P = 0.001) greater in NAION fellow eyes than in control eyes. There was no significant difference in optic disc area or vertical disc diameter among the control eyes, NAION-affected eyes, and NAION fellow eyes.CONCLUSIONS. Although patients with NAION have lower C/ D ratios than does the normal population, with a higher level of nerve fiber crowding, there was no difference in optic disc size between patients with NAION and control subjects. After the development of NAION, 47.8% of eyes had a C/ D ratio that differed from that in the fellow eye by more than 0.1.