OPM magnetorelaxometry in the presence of a DC bias field
OPM magnetorelaxometry in the presence of a DC bias field
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DOI：
10.1140/epjqt/s40507-020-00087-3
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发表时间：
2020-09-16
影响因子：
5.3
通讯作者：
Baumgarten, Daniel
中科院分区：
文献类型：
--
作者：
Jaufenthaler, Aaron;Schultze, Volkmar;Baumgarten, Daniel
磁性纳米粒子（MNP）分布的空间定量信息是磁热疗和磁性药物靶向等生物医学应用的先决条件。这些信息可以通过磁弛豫测量（MRX）成像来收集，其中通过灵敏的磁力计测量先前对齐的MNP磁矩的弛豫，并解决逆问题。为了消除或最大限度地减少磁屏蔽，其中MRX成像是今天进行的，背景磁场对MNP的弛豫的影响的知识是一个先决条件。我们使用强度调制光泵磁力计（OPM）在高达100 μ T的背景磁场中进行MRX测量。我们表明，松弛参数改变或可能故意改变显着通过施加静态场平行或反平行的MNP的排列方向。此外，不仅可以用OPM测量MNP的磁矩的弛豫过程，而且可以测量由于MRX激发场而导致的它们的排列。
Spatial quantitative information about magnetic nanoparticle (MNP) distributions is a prerequisite for biomedical applications like magnetic hyperthermia and magnetic drug targeting. This information can be gathered by means of magnetorelaxometry (MRX) imaging, where the relaxation of previously aligned MNP's magnetic moments is measured by sensitive magnetometers and an inverse problem is solved. To remove or minimize the magnetic shielding in which MRX imaging is carried out today, the knowledge of the influence of background magnetic fields on the MNP's relaxation is a prerequisite. We show MRX measurements using an intensity-modulated optically pumped magnetometer (OPM) in background magnetic fields of up to100 mu T. We show that the relaxation parameters alter or may be intentionally altered significantly by applying static fields parallel or antiparallel to the MNP's alignment direction. Further, not only the relaxation process of the MNP's magnetic moments could be measured with OPM, but also their alignment due to the MRX excitation field.