Severe Obesity as an Independent Risk Factor for COVID-19 Mortality in Hospitalized Patients Younger than 50
Severe Obesity as an Independent Risk Factor for COVID-19 Mortality in Hospitalized Patients Younger than 50
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DOI：
10.1002/oby.22913
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发表时间：
2020-08-02
期刊：
影响因子：
6.9
通讯作者：
Reich, David L.
中科院分区：
文献类型：
--
作者：
Klang, Eyal;Kassim, Gassan;Reich, David L.
目的 2019 年冠状病毒病 (COVID-19) 继续传播，年轻患者也受到严重影响。本研究将肥胖作为 50 岁以下住院患者死亡的独立危险因素进行分析。方法本研究回顾性分析了 2020 年 3 月 1 日至 2020 年 5 月 17 日期间在纽约市一家大型学术医院系统住院的 COVID-19 患者的数据。数据包括人口统计、合并症、体重指数和吸烟状况。肥胖组包括以下人群：BMI 为 30 至 < 40 kg/m(2) 和 BMI >= 40 kg/m(2)。多变量逻辑回归模型确定了与 50 岁以下和 50 岁以上患者死亡率独立相关的变量。 结果 总体而言，纳入了 3,406 名患者； 572 名 (17.0%) 患者年龄小于 50 岁。在较年轻的年龄组中，60 名 (10.5%) 患者死亡。在老年组中，有 1,076 名患者（38.0%）死亡。对于年轻人群，BMI >= 40 与死亡率独立相关（调整后优势比 5.1；95% CI：2.3-11.1）。对于老年人群，BMI >= 40 也与死亡率独立相关，但程度较小（调整后优势比 1.6；95% CI：1.2-2.3）。结论 这项研究表明，50 岁以下患有严重肥胖的住院患者更有可能死于 COVID-19。这在肥胖率很高的西方世界尤其重要。
Objective Coronavirus disease 2019 (COVID-19) continues to spread, and younger patients are also being critically affected. This study analyzed obesity as an independent risk factor for mortality in hospitalized patients younger than 50. Methods This study retrospectively analyzed data of patients with COVID-19 who were hospitalized to a large academic hospital system in New York City between March 1, 2020, and May 17, 2020. Data included demographics, comorbidities, BMI, and smoking status. Obesity groups included the following: BMI of 30 to < 40 kg/m(2)and BMI >= 40 kg/m(2). Multivariable logistic regression models identified variables independently associated with mortality in patients younger and older than 50. Results Overall, 3,406 patients were included; 572 (17.0%) patients were younger than 50. In the younger age group, 60 (10.5%) patients died. In the older age group, 1,076 (38.0%) patients died. For the younger population, BMI >= 40 was independently associated with mortality (adjusted odds ratio 5.1; 95% CI: 2.3-11.1). For the older population, BMI >= 40 was also independently associated with mortality to a lesser extent (adjusted odds ratio 1.6; 95% CI: 1.2-2.3). Conclusions This study demonstrates that hospitalized patients younger than 50 with severe obesity are more likely to die of COVID-19. This is particularly relevant in the Western world, where obesity rates are high.