Ionized magnesium concentration during liver transplantation, resection of the liver and cardiac surgery.
Ionized magnesium concentration during liver transplantation, resection of the liver and cardiac surgery.
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肝移植、肝脏切除和心脏手术期间的离子镁浓度。
DOI：
10.3109/00365519609088643
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Albrecht Bornscheuer
中科院分区：
文献类型：
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作者：
Wolf R. Külpmann;Elke Rademacher;Albrecht Bornscheuer
在这项研究中，我们调查了三组患者，第一次接受肝移植（n = 9），第二次肝切除（n = 7）和第三次心脏手术（n = 10）在手术过程中的离子和总镁浓度的变化。肝移植：离子镁浓度从0.58 mmol/L降至0.34 mmol/L，远低于参考区间（0.49-0.72 mmol/L），而总镁浓度仅从0.78 mmol/L降至0.67 mmol/L（参考区间：0.65-1.05 mmol/L）。由于大量输注血液制品，柠檬酸盐浓度从220 mumol/L升高至1925 mumol/L（无肝期）。它是负相关的离子镁浓度。肝脏切除：离子镁从0.56 mmol/L下降到0.43 mmol/L，略高于总镁从0.74 mmol/L下降到0.64 mmol/L。即使在未给予柠檬酸盐的情况下，柠檬酸盐浓度也适度增加，反映了手术期间肝功能降低。心脏手术：仅在输注柠檬酸盐而非镁的患者中，离子镁浓度略低于参考区间（0.45 mmol/L）。在其他患者中，给予镁，离子镁浓度在参考区间内或超过it. It的结论是，在肝功能受损和/或高柠檬酸负荷的患者中，离子镁浓度的监测是强制性的。
In this study we investigated three groups of patients, the first undergoing liver transplantation (n = 9), the second resection of the liver (n = 7) and the third cardiac surgery (n = 10) with regard to changes of ionized and total magnesium concentration during operation. Liver transplantation: Ionized magnesium concentration decreased from 0.58 mmol/L to 0.34 mmol/L far below the reference interval (0.49-0.72 mmol/L), whereas total magnesium concentration changed only from 0.78 mmol/L to 0.67 mmol/L (reference interval: 0.65-1.05 mmol/L). Citrate concentration increased from 220 mumol/L to 1925 mumol/L (anhepatic stage) because of massive transfusion of blood products. It was inversely correlated to ionized magnesium concentration. Resection of the liver: There was a decline of ionized magnesium from 0.56 mmol/L to 0.43 mmol/L, which slightly exceeded the decline of total magnesium from 0.74 mmol/L to 0.64 mmol/L. Citrate concentration increased moderately even in cases, when no citrate was administered reflecting reduced hepatic function during operation. Cardiac surgery: Only in patients, to whom citrate but not magnesium was infused, ionized magnesium concentration fell slightly below the reference interval (0.45 mmol/L). In the other patients, to whom magnesium was administered, ionized magnesium concentration was within the reference interval or exceeded it. It is concluded that in patients with impaired hepatic function and/or high citrate load the monitoring of ionized magnesium concentration is mandatory.