Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners
Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners
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DOI：
10.1016/j.sbi.2010.10.009
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发表时间：
2011-02-01
影响因子：
6.8
通讯作者：
Luisi, Ben F.
中科院分区：
文献类型：
--
作者：
Blower, Tim R.;Salmond, George P. C.;Luisi, Ben F.
许多原核生物表达毒素-抗毒素（TA）对，如果不保持微妙的平衡，就会对其宿主有害。维持潜在致命的毒素-抗毒素对可被视为一种高风险策略。然而，越来越多的证据表明，毒素-抗毒素对可以赋予选择性进化益处，例如适应性应激反应、饥饿恢复和对捕食的群体免疫。许多已知的 TA 对作为蛋白质相互作用，但最近的工作发现了一类新的抗毒素，即 RNA 裂解产物。结构研究揭示了不同毒素的共同折叠，强调了不同毒素类别中意想不到的进化关系。 TA 对似乎在功能上有很大差异，以满足不同原核宿主的特殊要求。
Many prokaryotes express toxin-antitoxin (TA) pairs that are harmful to their hosts if not maintained in delicate balance. The maintenance of potentially lethal toxin-antitoxin pairs could be viewed as a high-risk strategy. However, accumulating evidence suggests that toxin-antitoxin pairs can confer selective evolutionary benefits such as adaptive stress responses, starvation recovery and herd immunity to predation. Many of the known TA pairs interact as proteins, but recent work has identified a new class of antitoxins that are RNA cleavage products. Structural studies have revealed common folds for diverse toxins, highlighting unexpected evolutionary relationships within different toxin classes. TA pairs appear to have diverged in function considerably, to meet the specialised requirements of their varied prokaryotic hosts.