Simultaneous detection of apoptosis and proliferation in colorectal carcinoma by multiparameter flow cytometry allows separation of high and low‐turnover tumors with distinct clinical outcome
Simultaneous detection of apoptosis and proliferation in colorectal carcinoma by multiparameter flow cytometry allows separation of high and low‐turnover tumors with distinct clinical outcome
复制标题
通过多参数流式细胞术同时检测结直肠癌的凋亡和增殖，可以分离具有不同临床结果的高周转肿瘤和低周转肿瘤
作者：
J. D. Rupa;A. D. de Bruïne;Andrea J. Gerbers;M. Leers;M. Nap;A. Kessels;B. Schutte;J. Arends
Dukes C结直肠癌采用辅助化疗治疗。辅助治疗对于Dukes B肿瘤患者不是标准的，即使在该肿瘤阶段中约20%的患者死于复发性疾病。作者研究了同时检测细胞凋亡和增殖的新方法是否会改善结直肠癌患者的预后评估，最终目标是准确识别适合辅助治疗的患者。
Dukes C colorectal carcinoma is treated with adjuvant chemotherapy. Adjuvant treatment is not standard for patients with Dukes B tumors, even though about 20% of patients within this tumor stage die of recurrent disease. The authors investigated whether a novel method of simultaneous detection of apoptosis and proliferation would improve the assessment of prognosis in colorectal carcinoma patients, with the ultimate goal of accurately identifying patients eligible for adjuvant therapy.
影响因子：
158.5
作者：
VOGELSTEIN, B;FEARON, ER;BOS, JL
通讯作者：
BOS, JL
DOI：
10.1002/cyto.1097
发表时间：
2001-06-15
期刊：
CYTOMETRY
影响因子：
--
作者：
Bagwell, CB;Clark, GM;Baldetorp, B
通讯作者：
Baldetorp, B