Smoking is a risk factor in the progression to kidney failure
Smoking is a risk factor in the progression to kidney failure
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DOI：
10.1038/ki.2011.157
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发表时间：
2011-09-01
影响因子：
19.6
通讯作者：
Orth, Stephan R.
中科院分区：
文献类型：
--
作者：
Hallan, Stein I.;Orth, Stephan R.
为了研究吸烟在肾损害中的作用，我们测量了性别特异性效应、剂量反应关系以及戒烟是否降低了吸烟对未来肾衰竭的风险。在10.3年的中位随访期间，HUNT II研究的65，589名参与者中有124名（挪威人群）进展为5期慢性肾病。与从不吸烟者相比，入选时年龄小于70岁的既往和当前吸烟者发生肾衰竭的多重校正风险比分别为3.32和4.01。在男性中，风险随着累积吸烟（包年）的显著更高趋势而增加;然而，风险随着戒烟后的年数增加而显著降低。虽然目前吸烟的患病率在性别之间没有差异，但女性吸烟较少（10.2与15.8包-年），女性肾衰竭病例的数量低于男性（46与78）。吸烟对肾衰竭风险的影响相似（目前吸烟的女性和男性的风险比分别为2.94和4.30），但在女性中没有达到统计学意义。因此，在这个大规模的人群样本中，我们发现吸烟是未来肾衰竭的一个重要危险因素。戒烟降低了这种风险，至少在男性中是这样。Kidney International（2011）80，516-523; doi：10.1038/ki.2011.157; 2011年6月15日在线发表
To study the role of smoking in renal damage, we measured gender-specific effects, dose-response relationships, and whether cessation reduced the risk of smoking on future kidney failure. During a median follow-up of 10.3 years, 124 of 65,589 participants of the HUNT II study, a Norwegian population, progressed to stage 5 chronic kidney disease. Former-and current-smokers less than 70 years of age at inclusion had significant multi-adjusted hazard ratios of 3.32 and 4.01 for kidney failure compared to those who never smoked. In men, the risk increased with a significantly higher trend for cumulative smoking (pack-years); however, the risk significantly decreased with increased elapsed years since smoking cessation. Although the prevalence of current smoking did not differ between genders, females had smoked less (10.2 compared to 15.8 pack-years) and the number of kidney failure cases was lower in females than in men (46 compared to 78). The effect of smoking on the risk of kidney failure was similar (hazard ratios of 2.94 and 4.30 in current-smoking women and men, respectively), but did not reach statistical significance in women. Thus, in this large population-based sample, we found that smoking is a significant risk factor for future kidney failure. Smoking cessation decreased this risk, at least in men. Kidney International (2011) 80, 516-523; doi:10.1038/ki.2011.157; published online 15 June 2011