Proton beam therapy for hepatocellular carcinoma adjacent to the porta hepatis
Proton beam therapy for hepatocellular carcinoma adjacent to the porta hepatis
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DOI：
10.1016/j.ijrobp.2007.09.056
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发表时间：
2008-06-01
影响因子：
7
通讯作者：
Minami, Manabu
中科院分区：
文献类型：
--
作者：
Mizumoto, Masashi;Tokuuye, Koichi;Minami, Manabu
Purpose: To evaluate the efficacy and safety of proton beam therapy (PBT) for patients with hepatocellular carcinoma (HCC) located adjacent to the porta hepatis.Methods and Materials: Subjects of the study were 53 patients with HCC located within 2 cm of the main portal vein. All patients had tumor confined to the radiation field with no evidence of metastatic disease. All patients had hepatic function levels of a Child-Pugh score of 10 or less, Eastern Cooperative Oncology Group performance status of 2 or less, and no uncontrolled ascites. Patients underwent PBT of 72.6 GyE in 22 fractions from Sept 2001 to Dec 2004.Results: After 3 years, the actuarial survival rate was 45.1 % and local control rate was 86.0 %. Prognostic factors for survival included Child-Pugh score, number of tumors, and a-fetoprotein levels. No late treatment-related toxicity of Grade 2 or higher was observed.Conclusions: The PBT delivering 72.6 GyE in 22 fractions appears to be effective and safe for HCC adjacent to the porta hepatis. (c) 2008 Elsevier Inc.
