DUST-RELATED AND ENDOTOXIN-RELATED ACUTE LUNG-FUNCTION CHANGES AND WORK-RELATED SYMPTOMS IN WORKERS IN THE ANIMAL FEED-INDUSTRY
DUST-RELATED AND ENDOTOXIN-RELATED ACUTE LUNG-FUNCTION CHANGES AND WORK-RELATED SYMPTOMS IN WORKERS IN THE ANIMAL FEED-INDUSTRY
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DOI：
10.1002/ajim.4700250611
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发表时间：
1994-06-01
影响因子：
3.5
通讯作者：
QUANJER, PH
中科院分区：
文献类型：
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作者：
SMID, T;HEEDERIK, D;QUANJER, PH
在265名接触动物饲料的工人和一个由175名外部对照和动物饲料行业的非接触工人组成的对照组之间，对工作期间报告的呼吸道和相关症状进行了比较。提示呼吸道和鼻刺激的症状在动物饲料工人中显著增加。患病率从9%（咳嗽）到21%（打喷嚏）不等。报告的工作后咳嗽也明显增加。在119名工人中，共检测了457个交叉移位肺功能变化。几乎所有的肺功能变量在轮班期间都显示出降低，这是可以预期的，因为昼夜节律在测量期间（下午2点至下午4点）处于下降阶段。下午10时）。按工种分为粉尘和内毒素接触组，最大呼气中段流速（MMEF）和50%肺活量最大呼气流速（MEF 50）均呈肯定-反应趋势。内毒素的作用在强度和意义上均强于粉尘。对于相同的肺功能变量和1秒用力呼气量（FEV 1）和MEF 25，也检测到了显著的跨周变化。这项研究的结果与其他研究一致，表明在工作期间暴露于谷物粉尘对肺功能的急性影响和呼吸道症状的发病率升高。(C)1994 Wiley-Liss，Inc.
Reported respiratory and related symptoms during work were compared between 265 exposed animal feed workers and a control group consisting of 175 external controls and nonexposed workers in the animal feed industry. Symptoms indicating respiratory and nasal irritation were significantly increased in the animal feed workers. Prevalences ranged from 9% (cough) to 21% (sneezing). Reported cough after work was also significantly increased. In 119 workers, a total of 457 across-shift spirometric lung function changes were measured. Almost all lung function variables showed a decrease during the work shift, as could be expected since the circadian rhythm is in a downward phase during the measurement period (2 p.m.-10 p.m.). When the workers were grouped into dust and endotoxin exposure categories according to their job titles, and exposure-response trend was seen for maximum mid-expiratory flow (MMEF) and maximum expiratory flow rate at 50% of vital capacity (MEF50). The effect of endotoxin was stronger than that of dust, both in magnitude and significance. For the same lung function variables and for forced expiratory volume in 1 second (FEV1) and MEF25, a significant across-week change was also detected. The results of this study are in concordance with other studies that indicate acute effects on lung function and elevated prevalences of respiratory symptoms during work caused by exposure to grain dust. (C) 1994 Wiley-Liss, Inc.