Evaluation of ART Scores for Repeated Transarterial Chemoembolization in Japanese Patients with Hepatocellular Carcinoma
Evaluation of ART Scores for Repeated Transarterial Chemoembolization in Japanese Patients with Hepatocellular Carcinoma
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DOI：
10.1159/000440625
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发表时间：
2015-01-01
期刊：
影响因子：
3.5
通讯作者：
Kudo, Masatoshi
中科院分区：
文献类型：
--
作者：
Arizumi, Tadaaki;Ueshima, Kazuomi;Kudo, Masatoshi
目的：推荐经动脉化疗栓塞（TACE）作为不适合根治性治疗且无门脉侵犯的肝细胞癌（HCC）患者的一线治疗。最近提出了 TACE 再治疗评估 (ART) 评分系统，用于识别重复 TACE 无法显示出足够生存获益的患者。我们重新评估了 ART 在日本治疗的 HCC 患者中的效果，日本通常使用选择性 TACE。方法：2000年至2013年间，988例HCC患者在近畿大学医院接受了TACE，其中627例接受了≥2次TACE。研究人员对 90 天内接受≥2 次 TACE 治疗的 76 名患者的 ART 评分在总生存期 (OS) 方面的表现进行了调查。结果：只有 12% (76/627) 的患者在 90 天内接受了 2 次以上的 TACE 治疗。其中，52 名患者的 ART 评分较低（0-1.5），24 名患者的 ART 评分较高（>= 2.5）；中位 OS 分别为 20.2 个月和 37.6 个月 (p = 0.8207)。结论：ART 评分系统并未证明对 90 天内接受 2 次 TACE 治疗的患者的 OS 具有足够的预测影响。应仔细考虑 ART 评分的应用，因为 TACE 手术和 TACE 后治疗的差异会影响评估 OS 的结果。 (C) 2015 S. Karger AG，巴塞尔
Objective: Transarterial chemoembolization (TACE) is recommended as a first-line therapy for hepatocellular carcinoma (HCC) patients ineligible for curative therapy and without portal invasion. The Assessment for Retreatment with TACE (ART) scoring system was recently proposed for identifying patients who would not show sufficient survival benefit from repeated TACE. We reevaluated the performance of ART in HCC patients treated in Japan, where selective TACE is commonly used. Methods: Between 2000 and 2013, 988 patients with HCC underwent TACE at Kinki University Hospital, and 627 received >= 2 sessions of TACE. Seventy-six patients who underwent >= 2 TACE sessions within 90 days were investigated for their performance of the ART score in the context of overall survival (OS). Results: Only 12% (76/627) of patients underwent >= 2 TACE sessions within 90 days. Of those, 52 patients showed a low ART score (0-1.5), and 24 had a high ARTscore (>= 2.5); the median OS was 20.2 and 37.6 months, respectively (p = 0.8207). Conclusion:The ART scoring system did not demonstrate a sufficiently predictive impact on OS among the patients who underwent 2 TACE sessions within 90 days. Application of the ART score should be carefully considered because differences in TACE procedures and post-TACE treatment can affect the results while evaluating OS. (C) 2015 S. Karger AG, Basel