DIFFERENCES IN SENSITIVITY TO NEUROLEPTIC BLOCKADE - MEDIAL FOREBRAIN-BUNDLE VERSUS FRONTAL-CORTEX SELF-STIMULATION
DIFFERENCES IN SENSITIVITY TO NEUROLEPTIC BLOCKADE - MEDIAL FOREBRAIN-BUNDLE VERSUS FRONTAL-CORTEX SELF-STIMULATION
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DOI：
10.1016/0166-4328(90)90163-9
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发表时间：
1990-01-01
影响因子：
2.7
通讯作者：
CORBETT, D
中科院分区：
文献类型：
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作者：
CORBETT, D
在内侧前脑束和内侧前额叶皮层的电极部位测试了多巴胺受体拮抗剂顺式氟哌噻吨的全身注射对颅内自我刺激的影响。使用曲线移位范例评估脑刺激的奖励有效性的变化。低至中等剂量的顺式氟哌噻吨（0.05，0.1和0.15毫克/公斤）一致产生较大的向上移动的频率功能内侧前脑束比内侧前额叶自我刺激。在最高剂量的顺式氟噻吨（0.15和0.2毫克/公斤），一些内侧前脑束大鼠未能作出反应，而所有内侧前额叶大鼠在这些剂量作出反应。这些结果表明，内侧前脑束自我刺激比前额皮质自我刺激更依赖于多巴胺系统。
The effects of systemic injections of the dopamine receptor antagonist, cis-flupenthixol were tested on intracranial self-stimulation at electrode sites in the medial forebrain bundle and the medial prefrontal cortex. Changes in the reward effectiveness of the brain stimulation were assessed using a curve-shift paradigm. Low to moderate doses of cis-flupenthixol (0.05, 0.1 and 0.15 mg/kg) consistently produced larger upward shifts in the rate-frequency function for medial forebrain bundle than for medial prefrontal self-stimulation. At the highest doses of cis-flupenthixol (0.15 and 0.2 mg/kg), some of the medial forebrain bundle rats failed to respond, whereas all medial prefrontal rats responded at these doses. These results demonstrate that medial forebrain bundle self-stimulation is much more dependent on dopamine systems than is prefrontal cortex self-stimulation.