Body mass index and waist circumference predict both 10-year nonfatal and fatal cardiovascular disease risk: study conducted in 20 000 Dutch men and women aged 20-65 years
Body mass index and waist circumference predict both 10-year nonfatal and fatal cardiovascular disease risk: study conducted in 20 000 Dutch men and women aged 20-65 years
复制标题
DOI：
10.1097/hjr.0b013e328331dfc0
复制
发表时间：
2009-12-01
影响因子：
--
通讯作者：
Verschuren, W. M. Monique
中科院分区：
文献类型：
--
作者：
van Dis, Ineke;Kromhout, Daan;Verschuren, W. M. Monique
目的体重指数（BMI）和腰围（WC）是心血管疾病（CVD）的预测指标.我们比较了绝对风险，危险比（HR），非致命性和致命性CVD的BMI和WC在一个大型的前瞻性队列研究的平均随访10 years.Methods和结果的人口归因风险测量数据在1993年和1997年之间的一般人群样本超过20 000名男性和女性年龄在20-65岁在荷兰。所有风险均根据年龄和性别进行调整。非致命性CVD的绝对风险平均比致命性CVD高10倍。在肥胖的受访者中（BMI >= 30 kg/m2），致命性CVD的相对风险比正常体重的受访者高4倍[HR = 4.0 95%CI = 2.4-6.6]，而非致命性CVD的风险比正常体重的受访者高2倍（HR = 1.8 95%CI = 1.6-2.2）。观察到WC（男性>= 88 vs.< 80 cm in women and >= 102 vs. 94 cm）的类似关联。在超重或肥胖者中（BMI >= 25 kg/m2），半数致死性CVD（归因危险度= 54%，95% CI = 30-70）和四分之一非致死性CVD归因于超重。在人群水平上，三分之一的致死性CVD病例可归因于超重和肥胖（人群归因危险度= 35%，95%CI = 14-52），约七分之一的非致死性CVD病例可归因于超重和肥胖（人群归因危险度= 35%，95%CI = 14 - 52）。超重和肥胖对致命性CVD的影响比非致命性CVD更大。欧洲心脏病学会康复杂志16：729-734（C）2009
Aims Body mass index (BMI) and waist circumference (WC) are both predictors of cardiovascular diseases (CVD). We compared absolute risk, hazard ratio (HR), and population attributable risk of nonfatal and fatal CVD for BMI and WC in a large prospective cohort study with an average follow-up of 10 years.Methods and results Anthropometric data were measured between 1993 and 1997 in a general population sample of over 20 000 men and women aged 20-65 years in the Netherlands. All risks were adjusted for age and sex. Absolute risk of nonfatal CVD was on average 10 times higher than that of fatal CVD. In obese respondents (BMI >= 30 kg/m(2)), relative risk of fatal CVD was four-fold higher [HR = 4.0 95% confidence interval (CI) = 2.4-6.6], whereas risk of nonfatal CVD was twofold higher (HR = 1.8 95% CI = 1.6-2.2) than in normal-weight respondents. Similar associations were observed for WC (>= 88 vs. < 80 cm in women and >= 102 vs. 94 cm in men). In persons with overweight or obesity (BMI >= 25 kg/m(2)), half of all fatal CVD (attributable risk=54%, 95% CI = 30-70) and a quarter of nonfatal CVD was ascribed to their overweight. On the population level, one-third of all fatal CVD cases could be attributed to overweight and obesity (population attributable risk = 35%, 95% CI = 14-52), and about one in seven of nonfatal CVD cases.Conclusion The associations of BMI and WC with CVD risk were equally strong. Overweight and obesity had a stronger impact on fatal CVD than on nonfatal CVD. Eur J Cardiovasc Prev Rehabil 16:729-734 (C) 2009 The European Society of Cardiology