Antimicrobial resistance and COVID-19: Intersections and implications.
Antimicrobial resistance and COVID-19: Intersections and implications.
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DOI：
10.7554/elife.64139
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发表时间：
2021-02-16
期刊：
影响因子：
7.7
通讯作者：
Chandler CI
中科院分区：
文献类型：
--
作者：
Knight GM;Glover RE;McQuaid CF;Olaru ID;Gallandat K;Leclerc QJ;Fuller NM;Willcocks SJ;Hasan R;van Kleef E;Chandler CI
在2019冠状病毒（COVID-19）大流行开始之前，抗菌素耐药性（AMR）是全球公共卫生的首要任务之一。AMR已经是一个复杂的挑战，现在需要在不断变化的医疗保健环境中加以解决。在这里，我们分析了COVID-19在抗菌药物使用、感染预防和卫生系统方面的变化如何影响AMR的出现、传播和负担。加强手部卫生、减少国际旅行和减少择期住院手术可能会在短期内减少AMR病原体的选择和传播。然而，如果抗生素被更广泛地使用，随着标准医疗保健途径的崩溃，可能会出现相反的效果。COVID-19大流行已逾6个月，AMR的动态仍不明朗。我们呼吁AMR社区保持全球视野，同时设计微调的监测和研究，以继续改善我们对这些交叉公共卫生挑战的准备和应对。
Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR) was among the top priorities for global public health. Already a complex challenge, AMR now needs to be addressed in a changing healthcare landscape. Here, we analyse how changes due to COVID-19 in terms of antimicrobial usage, infection prevention, and health systems affect the emergence, transmission, and burden of AMR. Increased hand hygiene, decreased international travel, and decreased elective hospital procedures may reduce AMR pathogen selection and spread in the short term. However, the opposite effects may be seen if antibiotics are more widely used as standard healthcare pathways break down. Over 6 months into the COVID-19 pandemic, the dynamics of AMR remain uncertain. We call for the AMR community to keep a global perspective while designing finely tuned surveillance and research to continue to improve our preparedness and response to these intersecting public health challenges.