Mesenchymal stem cells regulate cytoskeletal dynamics and promote cancer cell invasion through low dose nitric oxide.
Mesenchymal stem cells regulate cytoskeletal dynamics and promote cancer cell invasion through low dose nitric oxide.
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间充质干细胞通过低剂量一氧化氮调节细胞骨架动力学并促进癌细胞侵袭。
DOI：
10.2174/1566524014666140724102301
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Li X;Li X;Xiang J;Li G
骨髓间充质干细胞（BMSCs）可以募集到肿瘤部位并整合到肿瘤基质中。当与骨髓间充质干细胞共培养时，其他弱转移的鼻咽癌细胞（NPC）显示出更高的转移能力。BMSCs在肿瘤环境中表现出巨噬细胞的特征。BMSCs在肿瘤环境中产生的一氧化氮可通过Ca ~（2+）/钙调蛋白（Ca 2 +/CaM）的方式将caldesmon转运至podosome，并通过侵袭伪足的形成促进NPC细胞的转移能力，从而使NPC细胞降解细胞外基质。因此，我们得出结论，骨髓间充质干细胞促进细胞迁移和侵袭通过一氧化氮诱导的旁分泌信号。
Bone marrow-derived mesenchymal stem cells (BMSCs) can be recruited to tumor sites and integrate into the stroma of tumors. When co-cultured with BMSCs, otherwise weakly metastatic nasopharyngeal carcinoma cells (NPC) showed improved metastatic ability. BMSCs in the tumor environment displayed the characteristics of macrophages. Nitric oxide produced by BMSCs in tumor environment could translocate caldesmon to podosome in Ca2+/calmodulin manner and promoted metastatic ability of NPC cells through invadopodia formation, with which the NPC cells degrade the extracellular matrix. Thus, we concluded that the BMSCs promoted cell migration and invasion through nitric oxide-induced paracrine signals.