Post-extinction conditional stimulus valence predicts reinstatement fear: relevance for long-term outcomes of exposure therapy.
Post-extinction conditional stimulus valence predicts reinstatement fear: relevance for long-term outcomes of exposure therapy.
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DOI：
10.1080/02699931.2014.930421
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发表时间：
2015
影响因子：
2.6
通讯作者：
Craske MG
中科院分区：
文献类型：
--
作者：
Zbozinek TD;Hermans D;Prenoveau JM;Liao B;Craske MG
焦虑症的暴露疗法是从恐惧条件反射和消除翻译而来的。虽然暴露疗法在治疗焦虑方面是有效的，但恐惧有时会在暴露后回归。恐惧回归的途径之一是恢复：在灭绝完成后无信号的无条件刺激。本研究探讨了在何种程度上的效价条件刺激（CS+）灭绝后预测返回CS+恐惧后恢复。参与者（N = 84）参与了差异恐惧条件反射范式，并随机恢复或不恢复。我们假设，更负的灭绝后CS+效价将预测更高的CS+恐惧恢复后，相对于非恢复和相对灭绝复检。结果支持的假设，并表明，旨在降低CS+的负效价的策略，可以减少通过恢复暴露治疗后的恐惧的回报。
Exposure therapy for anxiety disorders is translated from fear conditioning and extinction. While exposure therapy is effective in treating anxiety, fear sometimes returns after exposure. One pathway for return of fear is reinstatement: unsignaled unconditional stimuli following completion of extinction. The present study investigated the extent to which valence of the conditional stimulus (CS+) after extinction predicts return of CS+ fear after reinstatement. Participants (N = 84) engaged in a differential fear conditioning paradigm and were randomized to reinstatement or non-reinstatement. We hypothesized that more negative post-extinction CS+ valence would predict higher CS+ fear after reinstatement relative to non-reinstatement and relative to extinction retest. Results supported the hypotheses and suggest that strategies designed to decrease negative valence of the CS+ may reduce the return of fear via reinstatement following exposure therapy.