Role of nuclear factor-kappa B in atherogenesis
Role of nuclear factor-kappa B in atherogenesis
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DOI：
10.1113/expphysiol.1997.sp004025
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发表时间：
1997-03-01
影响因子：
2.7
通讯作者：
Baeuerle, PA
中科院分区：
文献类型：
--
作者：
Brand, K;Page, S;Baeuerle, PA
核因子-κ B（NF-κ B）/Rel家族的转录因子在参与细胞的炎症和增殖反应的多种基因的调节中具有重要功能。近年来的研究表明，诱导型转录因子NF-κ B B参与了动脉粥样硬化的发病机制。活化的NF-κ B B存在于动脉粥样硬化病变的纤维化增厚的内膜-中层和动脉粥样硬化区域，在平滑肌细胞、巨噬细胞和内皮细胞内，而在没有动脉粥样硬化的血管中可以检测到很少或没有活化的NF-κ B B。在动脉粥样硬化环境中已经鉴定出多种能够在体外激活NF-κ B的分子。此外，在动脉粥样硬化病变中发现许多已知受NF-κ B调节的基因表达增加。活化NF-κ B在动脉粥样硬化形成中可能的功能影响在这里进行了讨论。NF-κ B B在动脉粥样硬化中的激活和作用可能为转录因子参与人类慢性炎症性疾病提供了模型。
Transcription factors of the nuclear factor-kappa B (NF-kappa B)/Rel family have an important function in the regulation of a variety of genes involved in the inflammatory and proliferative responses of cells. Recent studies strongly indicate that the inducible transcription factor NF-kappa B is involved in the pathogenesis of atherosclerosis. Activated NF-kappa B is present in the fibrotic thickened intima-media and atheromatous areas of the atherosclerotic lesion, within smooth muscle cells, macrophages and endothelial cells, whereas little or no activated NF-kappa B can be detected in vessels lacking atherosclerosis. A variety of molecules have been identified in the atherosclerotic environment that are able to activate NF-kappa B in vitro. Furthermore, an increased expression of numerous genes known to be regulated by NF-kappa B has been found in the atherosclerotic lesion. Possible functional implications for activated NF-kappa B in atherogenesis are discussed here. The activation and role of NF-kappa B in atherosclerosis may provide a model for the involvement of the transcription factor in human chronic inflammatory disease.