Chemoselective Suzuki Coupling of Diborylmethane for Facile Synthesis of Benzylboronates
Chemoselective Suzuki Coupling of Diborylmethane for Facile Synthesis of Benzylboronates
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DOI：
10.1021/ol201115k
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发表时间：
2011-07-01
期刊：
影响因子：
5.2
通讯作者：
Shibata, Takanori
中科院分区：
文献类型：
--
作者：
Endo, Kohei;Ohkubo, Takahiro;Shibata, Takanori
报道了钯催化的Suzuki-Miyaura交叉偶联反应。使用等摩尔量的碱与二硼基甲烷实现化学选择性偶联用于合成各种苄基硼酸酯衍生物。空间位阻芳基溴可以以中等至优异的产率得到产物。
The chemoselective Pd-catalyzed Suzuki-Miyaura cross-coupling reaction using a diborylmethane is reported. The use of an equimolar amount of base with a diborylmethane realized chemoselective coupling for the synthesis of various benzylboronate derivatives. Sterically hindered aryl bromides can give products in moderate to excellent yields.