Ring closure to β-turn mimics via copper-catalyzed azide/alkyne cycloadditions
Ring closure to β-turn mimics via copper-catalyzed azide/alkyne cycloadditions
复制标题
DOI：
10.1021/jo0516180
复制
发表时间：
2005-11-11
影响因子：
3.6
通讯作者：
Burgess, K
中科院分区：
文献类型：
--
作者：
Angell, Y;Burgess, K
线形底物1的铜催化叠氮炔环加成反应生成环衍生物2。对这些化合物的计算、核磁共振和CD分析表明，它们最有利的构象包括I型和H型β转角构象。讨论了这些环化反应中二聚产物6的选择性。
Copper-catalyzed azide alkyne cycloadditions of the linear substrates 1 were used to form the cyclic derivatives 2. Computational, NMR, and CD analyses of these compounds indicate that their most favorable conformational states include type I and type H beta-turn conformations. Selectivity for the dimeric products 6 in these cyclization reactions is discussed.