Wolbachia, normally a symbiont of Drosophila, can be virulent, causing degeneration and early death
Wolbachia, normally a symbiont of Drosophila, can be virulent, causing degeneration and early death
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DOI：
10.1073/pnas.94.20.10792
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发表时间：
1997-09-30
影响因子：
11.1
通讯作者：
Benzer, S
中科院分区：
文献类型：
--
作者：
Min, KT;Benzer, S
沃尔巴克氏体是立克次体家族的一种母系传播微生物，已知其在多种昆虫物种中引起细胞质不相容性、孤雌生殖或雌性化。细菌与宿主的关系通常是共生的：受感染的雄性和未受感染的雌性之间的不相容性可以增强生殖隔离和进化，而其他机制可以增强后代的产生。我们发现了一种由黑腹果蝇携带的沃尔巴克氏体变体，这种亲密关系被废除，虽然在果蝇的发育过程中处于静止状态，但它在成年后开始大量增殖，导致广泛的组织退化，包括大脑，视网膜和肌肉，最终导致早期死亡。四环素处理后，带菌蝇的细菌和变性均被消除，恢复正常寿命。16s rDNA序列与已知的其他昆虫Wolbachia的一致性超过98%。在遗传实验中常用的黑腹果蝇的研究表明，大部分黑腹果蝇实际上携带非毒性形式的沃尔巴克氏体，这可能会影响它们的寿命和行为。
Wolbachia, a maternally transmitted microorganism of the Rickettsial family, is known to cause cytoplasmic incompatibility, parthenogenesis, or feminization in various insect species. The bacterium-host relationship is usually symbiotic: incompatibility between infected males and uninfected females can enhance reproductive isolation and evolution, whereas the other mechanisms enhance progeny production. We have discovered a variant Wolbachia carried by Drosophila melanogaster in which this cozy relationship is abrogated, Although quiescent during the fly's development, it begins massive proliferation in the adult, causing widespread degeneration of tissues, including brain, retina, and muscle, culminating in early death. Tetracycline treatment of carrier flies eliminates both the bacteria and the degeneration, restoring normal life-span, The 16s rDNA sequence is over 98% identical to Wolbachia known from other insects, Examination of laboratory strains of D. melanogaster commonly used in genetic experiments reveals that a large proportion actually carry Wolbachia in a nonvirulent form, which might affect their longevity and behavior.