Normal erythropoietic helper T cells in congenital hypoplastic (Diamond-Blackfan) anemia.
Normal erythropoietic helper T cells in congenital hypoplastic (Diamond-Blackfan) anemia.
复制标题
先天性发育不全（Diamond-Blackfan）贫血中的正常红细胞生成辅助 T 细胞。
DOI：
10.1056/nejm197805112981903
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
D. Housman
中科院分区：
文献类型：
--
作者：
D. Nathan;D. Hillman;L. Chess;B. Alter;B. Clarke;J. Bréard;D. Housman
To examine the erythropoietic function of T and null cells in congenital hypoplastic (Diamond-Blackfan) anemia, we fractionated the peripheral blood of three normal subjects and three affected patients into subclasses of null, T and B cells. Mixtures of these cells were co-cultured in plasma clots in the presence of erythropoietin. Erythroid colonies grew in cultures of normal null cells if either normal or patient T cells were co-cultured with them. Null cells of patients with hypoplastic anemia did not produce erythroid colonies under any culture conditions. We conclude that in this disorder, T cells function normally as helper cells in erythropoiesis and do not suppress colony formation, whereas the erythroid progenitor cells in the peripheral blood null-cell fractions are deficient in either number of function.
