Second messenger signalling in olfaction.
Second messenger signalling in olfaction.
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DOI：
10.1016/0959-4388(92)90177-m
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发表时间：
1992-08-01
影响因子：
5.7
通讯作者：
Boekhoff, I
中科院分区：
文献类型：
--
作者：
Breer, H;Boekhoff, I
嗅觉感受神经元的化学-电信号转导通路的主要反应是由两种交替的第二信使cAMP和1，4，5-三磷酸肌醇介导的。快速和短暂的细胞内信号传导被负反馈环的作用终止，负反馈环使反应级联解偶联（脱敏）。最近的证据表明，嗅觉的次级反应（适应）也可能是由第二信使控制的。
The primary reactions of the chemo-electrical signal transduction pathway in olfactory receptor neurons are mediated by two alternative second messengers, cAMP and inositol 1,4,5-trisphosphate. The rapid and transient intracellular signalling is terminated by the action of negative-feedback loops which uncouple the reaction cascades (desensitization). Recent evidence suggests that secondary reactions in olfaction (adaptation) may also be controlled by second messengers.