Castleman's disease in POEMS syndrome with elevated interleukin-6.
Castleman's disease in POEMS syndrome with elevated interleukin-6.
复制标题
POEMS 综合征中的 Castleman 病伴白细胞介素 6 升高。
DOI：
10.1002/1097-0142(19920601)69:11
复制
发表时间：
1992
期刊：
影响因子：
6.2
通讯作者：
Lotz,M
中科院分区：
文献类型：
--
作者：
Mandler,RN;Kerrigan,DP;Smart,J;Kuis,W;Villiger,P;Lotz,M
POEMS 综合征是一种罕见的多系统疾病，因其症状而闻名，它的缩写名称也由此而来，即“周围神经病变、器官肿大、内分泌病变、单克隆 (M) 蛋白和皮肤病变”。我们的研究记录了一名患有卡斯尔曼病（血管滤泡淋巴结增生）的年轻女性的这种综合征的病程。脑脊液 (CSF) 和血清白细胞介素 6 (IL-6) 水平在 % 月期间的不同时间异常升高。作者得出结论，与该患者 POEMS 综合征相关的浆细胞恶液质是 Castleman 病。血清 IL-6 水平升高可能与 POEMS 综合征的发病机制有关。Cancer1992； 69：2697-2703。
POEMS syndrome is a rare multisystem affliction known for its signs, from which it also takes its acronym name “peripheral neuropathy, organomegaly, endocrinopathy, monoclonal (M) protein, and skin lesions.” Our study chronicles the course of this syndrome in a young woman with Castleman's disease (angiofollicular lymph node hyperplasia). Cerebrospinal fluid (CSF) and serum interleukin‐6 (IL‐6) levels were abnormally elevated at various times during a %month period. The authors conclude that the plasma cell dyscrasia associated with the POEMS syndrome of this patient was Castleman's disease. Elevation of serum IL‐6 levels might contribute to the pathogenesis of the POEMS syndrome.Cancer1992; 69:2697‐2703.