The connections between neural crest development and neuroblastoma.
The connections between neural crest development and neuroblastoma.
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DOI：
10.1016/b978-0-12-380916-2.00004-8
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发表时间：
2011
影响因子：
--
通讯作者：
Lahti, Jill M.
中科院分区：
文献类型：
--
作者：
Jiang, Manrong;Stanke, Jennifer;Lahti, Jill M.
神经母细胞瘤（NB）是儿童期最常见的颅外实体瘤，在生物学和临床上都是一种非常异质性的疾病。虽然在确定NB的分子和遗传标记方面取得了重大进展，但这种疾病仍然是一个谜。由于NB被认为是一种胚胎性肿瘤，来源于外周（交感）神经系统的前体细胞，因此了解正常交感神经系统的发育可能会突出导致NB启动的异常事件。因此，本次审查的重点是外周干神经嵴的发展，目前的了解如何发展因素可能有助于NB和NB肿瘤发生和转移的重要遗传病变和信号通路的识别的最新进展。最后，我们讨论了如何在未来的进展，在NB的分子改变的识别可能会导致更有效，毒性更小的治疗，并改善NB患者的预后。
Neuroblastoma (NB), the most common extracranial solid tumor in childhood, is an extremely heterogeneous disease both biologically and clinically. Although significant progress has been made in identifying molecular and genetic markers for NB, this disease remains an enigmatic challenge. Since NB is thought to be an embryonal tumor that is derived from precursor cells of the peripheral (sympathetic) nervous system, understanding the development of normal sympathetic nervous system may highlight abnormal events that contribute to NB initiation. Therefore, this review focuses on the development of the peripheral trunk neural crest, the current understanding of how developmental factors may contribute to NB and on recent advances in the identification of important genetic lesions and signaling pathways involved in NB tumorigenesis and metastasis. Finally, we discuss how future advances in identification of molecular alterations in NB may lead to more effective, less toxic therapies, and improve the prognosis for NB patients.