Slow synaptic excitation mediated by serotonin in Auerbach's plexus
Slow synaptic excitation mediated by serotonin in Auerbach's plexus
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奥尔巴赫神经丛中血清素介导的缓慢突触兴奋
作者：
J. Wood;C. Mayer
Katayama和North报道了将低浓度的P物质应用于豚鼠肌间神经元，产生与输入电阻增加和兴奋性增强相关的去极化1。在此基础上，他们认为P物质可能参与了慢兴奋性突触后电位（e. p. s. p.）的产生。其可以通过电刺激神经节间连接在肌间神经元中诱发2。在这份报告中，我们表明，5-羟色胺（5-HT）的应用模拟缓慢的e. p. s. p.，并提出几条证据表明，5-HT是一个更可能的候选人的神经递质的慢ep. p. s. p.
THE application of low concentrations of substance P to guinea-pig myenteric neurones has been reported by Katayama and North to produce depolarisation associated with an increase in input resistance and augmented excitability1. On this basis, they suggested that substance P may be involved in the production of the slow excitatory postsynaptic potential (e.p.s.p.) which can be evoked in myenteric neurones by electrical stimulation of the interganglionic connectives2. In this report, we show that application of serotonin (5-HT) mimics the slow e.p.s.p., and present several lines of evidence which suggest that 5-HT is a more likely candidate for the neurotransmitter of the slow e.p.s.p.