Desipramine changes salivary gland function, oral microbiota, and oral health in rats.
Desipramine changes salivary gland function, oral microbiota, and oral health in rats.
复制标题
地昔帕明改变大鼠的唾液腺功能、口腔微生物群和口腔健康。
DOI：
10.1016/s0014-2999(00)00770-6
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发表时间：
2000
影响因子：
5
通讯作者：
Humphreys-Beher,MG
中科院分区：
文献类型：
--
作者：
Koller,MM;Maeda,N;Scarpace,PJ;Humphreys-Beher,MG
三环类抗抑郁药仍然是治疗抑郁症的主要精神治疗药物。口腔干燥是它们的主要副作用之一，导致人类口腔疾病增加以及言语、咀嚼、吞咽和味觉功能障碍。我们以前报道过三环类抗抑郁药地昔帕明使唾液腺中的β-肾上腺素能信号转导脱敏。在这项研究中，我们评估了这种治疗对大鼠腮腺和颌下腺功能、口腔微生物群和口腔健康的影响。总蛋白分泌和唾液α-淀粉酶不受治疗影响，而细胞α-淀粉酶和表皮生长因子含量受到抑制。十二烷基硫酸钠-聚丙烯酰胺凝胶电泳显示富含脯氨酸的蛋白质和糖蛋白的分泌增加。令人惊讶的是，流速暂时增加。唾液腺功能的这些改变可以部分解释观察到的口腔微生物群的变化和牙龈炎发病率的增加。在其他营养条件下，地昔帕明可能对口腔健康产生更严重的影响。
Tricyclic antidepressants are still a dominating group of psychotherapeutic drugs used in the treatment of depression. Oral dryness is one of their major side-effects, leading in humans to increased oral disease and dysfunction of speech, chewing, swallowing and taste. We previously reported that the tricyclic antidepressant desipramine desensitizes β-adrenergic signal transduction in salivary glands. In this study, we evaluated the effects of this treatment on parotid and submandibular gland function, oral microbiota, and oral health in rats. Total protein secretion and salivary α-amylase was not affected by treatment, while cellular α-amylase and the content of epidermal growth factor was depressed. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis revealed increased secretion for proline-rich proteins and glycoproteins. Surprisingly, flow rates were temporarily increased. These alterations in salivary gland function may partially explain the observed changes in oral microbiota and the increased incidence of gingivitis. Under other nutritional conditions, desipramine might have more severe impacts on oral health.