Glucagon-like peptide-1:: a potent regulator of food intake in humans
Glucagon-like peptide-1:: a potent regulator of food intake in humans
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DOI：
10.1136/gut.44.1.81
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发表时间：
1999-01-01
期刊：
影响因子：
24.5
通讯作者：
Beglinger, C
中科院分区：
文献类型：
--
作者：
Gutzwiller, JP;Göke, B;Beglinger, C
背景/目的-动物研究表明胰高血糖素样肽-1-（7-36）-酰胺（GLP-1）在调节饱腹感中的生理作用。GLP-1在调节人的食物摄入中的作用，然而，还没有被研究。（0，0.375，0.75，和1.5 pmol/kg/min）的合成人GLP-1对食物摄入以及饥饿感和饱腹感的影响。1输注导致食物摄入量的剂量依赖性减少（最大抑制35%，p
Background/Aims-Studies in animals suggest a physiological role for glucagonlike peptide-1-(7-36)-amide (GLP-1) in regulating satiety. The role of GLP-1 in regulating food intake in man has, however, not been investigated.Subjects-Sixteen healthy male subjects were examined in a double blind placebo controlled fashion.Methods-The effect of graded intravenous doses (0, 0.375, 0.75, and 1.5 pmol/kg/min) of synthetic human GLP-1 on food intake and feelings of hunger and satiety was tested in healthy volunteers.Results-Graded GLP-1 infusions resulted in a dose dependent reduction in food intake (maximal inhibition 35%, p