Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial
Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial
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DOI：
10.3945/ajcn.115.119339
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发表时间：
2016-03-01
影响因子：
7.1
通讯作者：
Phillips, Stuart M.
中科院分区：
文献类型：
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作者：
Longland, Thomas M.;Oikawa, Sara Y.;Phillips, Stuart M.
背景：在能量不足时，饮食中蛋白质的摄入量高于推荐膳食摄入量有助于保持瘦体重（LBM），特别是在与运动相结合时。目的：本研究的目的是进行一项原理证明试验，以测试在明显的能量不足期间，在进行高强度运动训练的同时，控制饮食蛋白质摄入量是否会影响身体成分的变化。设计：我们采用单盲、随机、平行组前瞻性试验。在4周的时间里，我们为年轻男性提供低能量（与需求相比减少40%）的饮食，提供33 +/- 1 kcal/kg LBM，随机分配（n = 20/组）消耗低蛋白质（1.2 g）。公斤(1)。d(-1))对照饮食（CON）或高蛋白饮食（2.4 g）。公斤(1)。d(-1))日粮（PRO）。所有受试者均进行阻力运动训练和高强度间歇训练，每次6天/周。干预前后分别采用四室模型评估体成分。结果：干预后，PRO组（1.2 +/- 1.0 kg）的LBM较CON组（0.1 +/- 1.0 kg）增加（P < 0.05），且增加幅度更大（P < 0.05）。PRO组脂肪减少量大于CON组（PRO:-4.8 +/- 1.6 kg; CON:-3.5 +/- 1.4kg; P < 0.05）。在没有补充蛋白质影响的干预下，PRO组和CON组的所有运动表现指标都得到了类似的改善。干预期间血清皮质醇的变化与体脂（r = 0.39, P = 0.01）和LBM （r = -0.34, P = 0.03）的变化相关。结论：我们的研究结果表明，在明显的能量不足期间，摄入含有2.4克蛋白质的饮食。公斤(1)。D（-1）比摄入含有1.2 g蛋白质的饮食更有效。公斤(1)。d（-1）在与高强度阻力和无氧运动相结合时，促进LBM的增加和脂肪量的减少。血清皮质醇的变化与体脂和LBM的变化有关，但并不能解释两种测量方法的差异。该试验在clinicaltrials.gov注册为NCT01776359。
Background: A dietary protein intake higher than the Recommended Dietary Allowance during an energy deficit helps to preserve lean body mass (LBM), particularly when combined with exercise.Objective: The purpose of this study was to conduct a proof-of principle trial to test whether manipulation of dietary protein intake during a marked energy deficit in addition to intense exercise training would affect changes in body composition.Design: We used a single-blind, randomized, parallel-group prospective trial. During a 4-wk period, we provided hypoenergetic (similar to 40% reduction compared with requirements) diets providing 33 +/- 1 kcal/kg LBM to young men who were randomly assigned (n = 20/group) to consume either a lower-protein (1.2 g . kg(-1) . d(-1)) control diet (CON) or a higher-protein (2.4 g . kg(-1) . d(-1)) diet (PRO). All subjects performed resistance exercise training combined with high intensity interval training for 6 d/wk. A 4-compartment model assessment of body-composition was made pre- and postintervention.Results: As a result of the intervention, LBM increased (P < 0.05) in the PRO group (1.2 +/- 1.0 kg) and to a greater extent (P < 0.05) compared with the CON group (0.1 +/- 1.0 kg). The PRO group had a greater loss of fat mass than did the CON group (PRO:-4.8 +/- 1.6 kg; CON:-3.5 +/- 1.4kg; P < 0.05). All measures of exercise performance improved similarly in the PRO and CON groups as a result of the intervention with no effect of protein supplementation. Changes in serum cortisol during the intervention were associated with changes in body fat (r = 0.39, P = 0.01) and LBM (r = -0.34, P = 0.03).Conclusions: Our results showed that, during a marked energy deficit, consumption of a diet containing 2.4 g protein . kg(-1) . d(-1) was more effective than consumption of a diet containing 1.2 g protein . kg(-1) . d(-1) in promoting increases in LBM and losses of fat mass when combined with a high volume of resistance and anaerobic exercise. Changes in serum cortisol were associated with changes in body fat and LBM, but did not explain much variance in either measure. This trial was registered at clinicaltrials.gov as NCT01776359.