[Updates on ossification of posterior longitudinal ligament. Ossification front of posterior longitudinal ligament and cellular biological assessment of chronic mechanical compressed spinal cord].
[Updates on ossification of posterior longitudinal ligament. Ossification front of posterior longitudinal ligament and cellular biological assessment of chronic mechanical compressed spinal cord].
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发表时间：
2009-10
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通讯作者：
K. Uchida;H. Nakajima;T. Yayama;R. Sato;H. Baba
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作者：
K. Uchida;H. Nakajima;T. Yayama;R. Sato;H. Baba
后纵韧带骨化（OPLL）的骨化过程、病理变化和脊髓病症状的治疗/评估机制仍不清楚。OPLL的软骨内骨化过程与弹性纤维和软骨形成的退行性改变、化生性肥大软骨细胞和新生血管的出现密切相关。混合型和局限型OPLL细胞因子和转录因子的表达程度存在差异。而慢性压迫的脊髓可能具有可塑性;使用干细胞植入物、补充神经营养因子，加上手术治疗，可能会带来更好的临床结果，鼓励这些基础研究的发展。使用新的成像技术进行评估需要确定受影响的程度并判断症状的严重程度。
Mechanisms of ossification processes, pathological changes, and treatment/assessment of myelopathy symptoms because of ossification of the posterior longitudinal ligament (OPLL) remain obscure. Enchondral ossification process of OPLL was closely associated with degenerative changes of elastic fibers and cartilage formation, together with the appearance of metaplastic hypertrophic cartilage cells and neovascularization. There are differences in expression degrees of cytokines and transcription factors between mixed and localized OPLL. While the chronic compressed spinal cord may have plasticity ; the use of stem cell implants, supplementation of neurotrophic factors, in addition to surgical treatment, may bring a better clinical outcome,encouraging the development of these basic research studies. Assessment using new imaging techniques needs to determine the affected level and judge the severity of symptoms.