Studies toward the pharmacophore of salvinorin A, a potent κ opioid receptor agonist
Studies toward the pharmacophore of salvinorin A, a potent κ opioid receptor agonist
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DOI：
10.1021/jm049438q
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发表时间：
2005-01-27
影响因子：
7.3
通讯作者：
Yan, F
中科院分区：
文献类型：
--
作者：
Munro, TA;Rizzacasa, MA;Yan, F
Salvinorin A (1), from the sage Salvia divinorum, is a potent and selective K opioid receptor (KOR) agonist. We screened other salvinorins and derivatives for binding affinity and functional activity at opioid receptors. Our results suggest that the methyl ester and furan ring are required for activity but that the lactone and ketone functionalities are not. Other salvinorins showed negligible binding affinity at the KOR. None of the compounds bound to mu or delta opioid receptors.
