Background gamma rhythmicity and attention in cortical local circuits:: A computational study
Background gamma rhythmicity and attention in cortical local circuits:: A computational study
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DOI：
10.1073/pnas.0502366102
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发表时间：
2005-05-10
影响因子：
11.1
通讯作者：
Kopell, NJ
中科院分区：
文献类型：
--
作者：
Börgers, C;Epstein, S;Kopell, NJ
我们描述了一个简单的计算模型，基于皮质局部回路的一般特征，将胆碱能神经调节、伽马节律性和注意力选择联系起来。我们提出，胆碱能调节通过减少主细胞的适应电流，诱导从异步自发活动向“背景”伽马节律（类似于胆碱能激动剂在体外诱发的持续伽马节律）的转变，其中单个主细胞很少且不规则地参与其中。我们认为，这种节奏伴随着准备性注意力或警惕性的状态，并报告模拟，证明它们的存在可以放大特定刺激的反应并增强局部回路内的刺激竞争。
We describe a simple computational model, based on generic features of cortical local circuits, that links cholinergic neuromodulation, gamma rhythmicity, and attentional selection. We propose that cholinergic modulation, by reducing adaptation currents in principal cells, induces a transition from asynchronous spontaneous activity to a "background" gamma rhythm (resembling the persistent gamma rhythms evoked in vitro by cholinergic agonists) in which individual principal cells participate infrequently and irregularly. We suggest that such rhythms accompany states of preparatory attention or vigilance and report simulations demonstrating that their presence can amplify stimulus-specific responses and enhance stimulus competition within a local circuit.