Computational cardiac anatomy using MRI
Computational cardiac anatomy using MRI
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DOI：
10.1002/mrm.20255
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发表时间：
2004-11-01
影响因子：
3.3
通讯作者：
Winslow, RL
中科院分区：
文献类型：
--
作者：
Beg, MF;Helm, PA;Winslow, RL
心脏病患者的心室几何结构和纤维取向可能发生整体或局部重塑。然而，目前还没有数学和计算方法来量化疾病中几何形状和纤维取向的变化或其重塑的性质。为了实现这一目标，开发了一种基于地标和图像强度的大变形几何度量映射（LDDMM）方法，将心脏几何形状转换为公共坐标，用于形状和形式的量化。提出了两种用于对不同心脏病理中预期的组织变形进行建模的自动标志放置方法。使用地标和图像强度的组合使用计算的变换，即使在存在心脏形状和形式的显著变化的情况下，也产生心脏解剖结构的高配准精度。一旦已经配准了心脏解剖，就可以量化不同心脏的对应区域中的组织几何形状和心脏纤维取向的性质。Magn Reson Med 52：1167-1174，2004. 2004年出版Wiley-Liss，Inc（匕首）。
Ventricular geometry and fiber orientation may undergo global or local remodeling in cardiac disease. However, there are as yet no mathematical and computational methods for quantifying variation of geometry and fiber orientation or the nature of their remodeling in disease. Toward this goal, a landmark and image intensity-based large deformation diffeomorphic metric mapping (LDDMM) method to transform heart geometry into common coordinates for quantification of shape and form was developed. Two automated landmark placement methods for modeling tissue deformations expected in different cardiac pathologies are presented. The transformations, computed using the combined use of landmarks and image intensities, yields high-registration accuracy of heart anatomies even in the presence of significant variation of cardiac shape and form. Once heart anatornies have been registered, properties of tissue geometry and cardiac fiber orientation in corresponding regions of different hearts may be quantified. Magn Reson Med 52: 1167-1174, 2004. Published 2004 Wiley-Liss, Inc(dagger).