Studies on pseudorabies (infectious bulbar paralysis, mad itch) I. Histology of the disease, with a note on the symptomatology
Studies on pseudorabies (infectious bulbar paralysis, mad itch) I. Histology of the disease, with a note on the symptomatology
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DOI：
10.1084/jem.58.4.415
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发表时间：
1933-10-01
影响因子：
15.3
通讯作者：
Hurst, EW
中科院分区：
文献类型：
--
作者：
Hurst, EW
伪狂犬病的组织学在不同的动物中有很大的不同。在兔体内，皮下、皮内或肌肉内接种可导致局部炎症和坏死。感染上升到周围神经(可能是中间和轴突)，到达相应的脊神经节和脊髓节段，在那里发生神经和神经胶质细胞的初级退化。神经细胞的变化可能是瘙痒的原因。病毒到达延髓后不久，在这里产生明显的变化之前，死亡就接踵而至。脑内接种后，脑膜、软膜下神经胶质细胞和浅层神经细胞出现特征性病变。肺部的病态变化不一定与病毒的存在有关，但可能会发生特定的病变。核内包涵体存在于所有胚层来源的细胞中，与疱疹病毒性脑炎、黄热病等的核内含物有一些相似之处。在豚鼠身上，这种疾病与兔子的疾病非常相似，只是它们的抵抗力稍强一些。在猴脑内接种后，皮质神经细胞广泛变性和坏死，并伴有神经和神经胶质细胞的特异性核改变，而中胚层起源的细胞则没有。其他脏器未见病变。在奶牛的自发性疾病中，病变与猴子的病变比与兔子的病变更接近。在猪中，血管和间质病变占主导地位，神经细胞变性相对较轻，没有观察到典型的包涵体；这些差异可能解释了皮下接种后的良性过程。淋巴系统也参与了对病毒的反应。
The histology of pseudorabies differs materially in various animals. In rabbits, subcutaneous, intradermal or intramuscular inoculation led to local inflammation and necrosis. Infection ascends the peripheral nerve (possibly both in-terstitially and by the axis-cylinders) to the corresponding spinal ganglia and segments of the spinal cord, where primary degeneration of nerve and glial cells takes place. The nerve-cell changes are probably responsible for the itching. Death ensues soon after virus reaches the medulla, before visible changes have been produced here. Intracerebral inoculation was followed by characteristic lesions in the meninges, in subpial glial cells, and in superficially placed nerve cells. Morbid changes in the lungs are not necessarily related to presence of virus, but specific lesions may develop. Intranuclear inclusions bearing some resemblance to those in herpetic encephalitis, yellow fever, etc., occur in cells derived from all embryonic layers. In guinea pigs, the disease resembles closely that in rabbits, and is modified only by their slightly greater resistance. In monkeys, after intracerebral inoculation, widespread degeneration and necrosis of cortical nerve cells were accompanied by specific nuclear alterations in nerve and glial cells, but not in cells of mesodermal origin. No lesions are found in other viscera. In the spontaneous disease in cows, lesions approximate more closely those in monkeys than those in rabbits. In pigs, vascular and interstitial lesions predominate, nerve cell degeneration is relatively slight, and typical inclusions are not observed; these differences probably explain the benign course following subcutaneous inoculation. The lymphatic system, too, participates in reactions to the virus.