Human immune response against timothy grass pollen allergens. I. Shared idiotypes on human and murine antigen-B-specific lymphocyte receptors.
Human immune response against timothy grass pollen allergens. I. Shared idiotypes on human and murine antigen-B-specific lymphocyte receptors.
复制标题
人体对梯牧草花粉过敏原的免疫反应。
DOI：
10.1159/000234977
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Malley,A
中科院分区：
文献类型：
--
作者：
Malley,A
Enzyme-linked immunoassays were used to examine the binding specificity of affinity-purified anti-idiotypic antibody [against the idiotypic determinant on timothy grass pollen antigen B (AgB)-specific IgE] with murine AgB-specific IgG and IgE antibodies, and the serum from timothy-sensitive patients. In addition, the proliferative response of peripheral blood lymphocytes from timothy-sensitive patients with either antigen or anti-idiotypic antibody was examined. These studies suggest that the idiotypic determinant expressed on murine AgB-specific IgE is highly conserved on human AgB-specific IgE and T cells of timothy-sensitive patients.
