Reduction of mitochondria and up regulation of pyruvate dehydrogenase kinase 4 of skeletal muscle in patients with chronic kidney disease
Reduction of mitochondria and up regulation of pyruvate dehydrogenase kinase 4 of skeletal muscle in patients with chronic kidney disease
复制标题
慢性肾病患者骨骼肌线粒体减少和丙酮酸脱氢酶激酶4上调
作者：
Xu Chenqi;Kasimumali Ayijiaken;Guo Xiangjiang;Lu Renhua;Xie Kewei;Zhu Mingli;Qian Yingying;Chen Xiaohuan;Pang Huihua;Wang Qin;Fan Zhuping;Dai Huili;Mou Shan;Ni Zhaohui;Gu Leyi
Muscle weakness is commonly among chronic kidney disease (CKD) patients. Muscle mitochondrial dysfunction and decreased pyruvate dehydrogenase (PDH) activity occur in CKD animals but have not been confirmed in humans, and changes in pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase phosphatase (PDP) expression have not been evaluated in CKD muscle. We presume that the reduction of muscle mitochondria and post‐translational modification of PDH may cause muscle weakness in CKD patients. Herein, we explored changes in mitochondrial morphology, PDH expression and activity, and PDK/PDP expression in CKD patient muscle.
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影响因子：
5.8
作者：
Holick, Michael F.;Binkley, Neil C.;Weaver, Connie M.
通讯作者：
Weaver, Connie M.
DOI：
10.1083/jcb.200211046
发表时间：
2003-01-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chen H;Detmer SA;Ewald AJ;Griffin EE;Fraser SE;Chan DC
通讯作者：
Chan DC
DOI：
10.1093/ndt/17.7.1266
发表时间：
2002-07
期刊：
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
影响因子：
--
作者：
P. Stenvinkel;P. Bárány;S. Chung;B. Lindholm;O. Heimbürger
通讯作者：
P. Stenvinkel;P. Bárány;S. Chung;B. Lindholm;O. Heimbürger
影响因子：
19.6
作者：
Johansen, KL;Shubert, T;Kent-Braun, JA
通讯作者：
Kent-Braun, JA
DOI：
10.1152/ajpendo.2000.278.2.e219
发表时间：
2000-02-01
影响因子：
5.1
作者：
Adey, D;Kumar, R;Nair, KS
通讯作者：
Nair, KS