Tract-Specific Group Analysis in Fetal Cohorts Using in utero Diffusion Tensor Imaging.
Tract-Specific Group Analysis in Fetal Cohorts Using in utero Diffusion Tensor Imaging.
复制标题
使用子宫内弥散张量成像对胎儿队列进行特定群体分析。
DOI：
10.1007/978-3-030-00931-1_4
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Gholipour,Ali
中科院分区：
文献类型：
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作者：
Khan,Shadab;Rollins,CaitlinK;Ortinau,CynthiaM;Afacan,Onur;Warfield,SimonK;Gholipour,Ali
基于扩散张量成像（DTI）的组分析有助于揭示白色损伤在从早产儿到成人的广泛研究中的影响。然而，这些方法在胎儿队列中的应用受到不受约束的胎儿运动、有限的扫描时间和有限的信噪比所引起的宫内胎儿DTI的挑战性性质的阻碍。我们提出了一个框架，解决这些问题，系统地评估胎儿队列的组间差异。一种运动鲁棒的DTI计算方法与一种新的无偏DTI模板构建方法是统一的核回归年龄和张量特定的注册，以规范化的无偏空间中的DTI体积。一个强大的统计方法被用来映射特定区域的组差异的中间表示的感兴趣的道。该方法首次应用于先天性心脏病胎儿和年龄匹配的健康对照胎儿的子宫DTI，并显示了局部白色物质各向异性分数的差异。本文建议需要胎儿特定的管道用于DTI为基础的组分析，涉及胎儿队列。
Diffusion tensor imaging (DTI) based group analysis has helped uncover the impact of white matter injuries in a wide range of studies involving subjects from preterm neonates to adults. The application of these methods to fetal cohorts, however, has been hampered by the challenging nature ofin uterofetal DTI caused by unconstrained fetal motion, limited scan times, and limited signal-to-noise ratio. We present a framework that addresses these issues to systematically evaluate group differences in fetal cohorts. A motion-robust DTI computation approach with a new unbiased DTI template construction method is unified with kernel-regression in age and tensor-specific registration to normalize DTI volumes in an unbiased space. A robust statistical approach is used to map region-specific group differences to the medial representation of the tracts of interest. The proposed approach was applied and showed, for the first time, differences in local white matter fractional anisotropy based onin uteroDTI of fetuses with congenital heart disease and age-matched healthy controls. This paper suggests the need for fetal-specific pipelines to be used for DTI-based group analysis involving fetal cohorts.