Syntheses of Structurally-simplified and Fluorescently-labeled Neovibsanin Derivatives and Analysis of their Neurite Outgrowth Activity in PC12 Cells.
Syntheses of Structurally-simplified and Fluorescently-labeled Neovibsanin Derivatives and Analysis of their Neurite Outgrowth Activity in PC12 Cells.
复制标题
结构简化和荧光标记的 Neovibsanin 衍生物的合成及其在 PC12 细胞中神经突生长活性的分析。
DOI：
10.1016/j.bmcl.2012.01.006
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Y. Fukuyama
中科院分区：
文献类型：
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作者：
H.Imagawa;H. Siajo;H. Yamaguchi;K. Maekwa;T. Kurisaki;H. Yamamoto;M. Nishizawa;M. Oda;M. Kaubura;M. Nagahama;J. Sakurai;M. Nakai;K. Makino;M. Ogata;H. Takahashi;Y. Fukuyama
几个neovibsanin衍生物的合成进行，以阐明显示神经突生长活性所需的简单结构。此外，合成了荧光探针分子，并对其在PC12细胞系中的行为进行了分析，结果表明，neovibsanins积累在细胞外边缘的位点上形成的粘附性。
The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsanins accumulate on the outer edge of the cell at the site of formation of prominences.