Quantitative cellular description of gastric slow wave activity
Quantitative cellular description of gastric slow wave activity
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DOI：
10.1152/ajpgi.00528.2007
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发表时间：
2008-04-01
影响因子：
4.5
通讯作者：
Buist, Martin L.
中科院分区：
文献类型：
--
作者：
Corrias, Alberto;Buist, Martin L.
胃慢波活动的定量细胞描述。[J] .中国生物医学工程学报，2009,31(2):589 - 595。首次发表于2008年2月6日；doi: 10.1152 / ajpgi.00528.2007。Cajal间质细胞（ICC）负责自发和无所不在的胃电活动。胞内过程的定量描述，其协调活动被认为产生电慢波已经发展，并在这里提出。与最近的实验证据一致，该模型描述了线粒体和内质网在细胞内Ca2+循环中的相互作用如何为慢波的起始提供主要的调节信号。已确定的影响慢波活动的主要离子通道已根据从孤立ICC获得的数据进行了建模。通过将模拟的慢波剖面与实验记录进行比较，该模型得到了验证，在对照和药理学改变条件下，慢波在频率、幅度和形状方面都表现出良好的一致性。
Quantitative cellular description of gastric slow wave activity. Am J Physiol Gastrointest Liver Physiol 294: G989-G995, 2008. First published February 6, 2008; doi:10.1152/ajpgi.00528.2007. Interstitial cells of Cajal (ICC) are responsible for the spontaneous and omnipresent electrical activity in the stomach. A quantitative description of the intracellular processes whose coordinated activity is believed to generate electrical slow waves has been developed and is presented here. In line with recent experimental evidence, the model describes how the interplay between the mitochondria and the endoplasmic reticulum in cycling intracellular Ca2+ provides the primary regulatory signal for the initiation of the slow wave. The major ion channels that have been identified as influencing slow wave activity have been modeled according to data obtained from isolated ICC. The model has been validated by comparing the simulated profile of the slow waves with experimental recordings and shows good correspondence in terms of frequency, amplitude, and shape in both control and pharmacologically altered conditions.