Relation between habitual diet and canine mammary tumors in a case-control study
Relation between habitual diet and canine mammary tumors in a case-control study
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DOI：
10.1111/j.1939-1676.1998.tb02108.x
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发表时间：
1998-05-01
影响因子：
2.6
通讯作者：
Cuesta, P
中科院分区：
文献类型：
--
作者：
Alenza, DP;Rutteman, GR;Cuesta, P
在本病例对照研究中，研究了几种饮食和营养因素，以确定饮食与雌性犬乳腺肿瘤的发展之间是否存在关系。对照雌性犬（n = 86）与患有乳腺发育不良或肿瘤的犬（n = 102）进行比较。主人回答了一份问卷，提供了狗的身体结构、饮食和生殖史的信息。分析血清硒和视黄醇浓度以及皮下脂肪组织中的脂肪酸分布作为营养状况的指标。发现1岁及诊断乳腺结节前1年的肥胖与乳腺肿瘤和发育不良的高患病率显著相关。自制食物的摄入量（与商业食品相比）也与更高的肿瘤和发育不良发生率显著相关。其他重要的风险因素是大量摄入红肉，尤其是牛肉和猪肉，以及少量摄入鸡肉。除C18: 1脂肪酸（油酸）含量显著高于健康对照组外，皮下脂肪酸分布和血清硒浓度与对照组无显著差异。这些病例的血清视黄醇浓度明显低于对照组。在多变量分析中，年龄较大、1岁时肥胖和大量摄入红肉与发生乳腺肿瘤和发育不良的风险独立且显著相关。
In the present case-control study several dietary and nutritional factors were investigated to determine if a relationship exists between diet and development of mammary tumors in female dogs. Control female dogs (n = 86) were compared with a case group of dogs (n = 102) with dysplasias or tumors of the mammary gland. A questionnaire providing information on the dog's body conformation and dietary and reproductive histories was answered by the owners. Serum selenium and retinol concentrations and the fatty acid profile in subcutaneous adipose tissue were analyzed as indicators of nutritional status. Obesity at 1 year of age and 1 year before the diagnosis of mammary nodules was found to be significantly related to a higher prevalence of mammary tumors and dysplasias. The intake of homemade meals (compared to that of commercial foods) was also significantly related to a higher incidence of tumors and dysplasias. Other significant risk factors were a high intake of red meat, especially beef and pork, and a low intake of chicken. The subcutaneous fatty acid profile and the serum selenium concentration were not significantly different in the cases and the controls, with the exception of C18:I fatty acid (oleic acid) content, which was significantly higher in the cases than in healthy controls. Serum retinol concentration was significantly lower in the cases than in the controls. In the multivariate analysis, older age, obesity at 1 year of age, and a high red meat intake were independently and significantly associated with the risk of developing mammary tumor and dysplasias.