Differential roles of monkey striatum in learning of sequential hand movement
Differential roles of monkey striatum in learning of sequential hand movement
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DOI：
10.1007/pl00005669
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发表时间：
1997-06-01
影响因子：
2
通讯作者：
Rand, MK
中科院分区：
文献类型：
--
作者：
Miyachi, S;Hikosaka, O;Rand, MK
为了研究基底神经节在顺序运动学习中的作用，我们训练两只猴子执行顺序按钮按压任务（2x 5任务）。这项任务使我们能够检查学习新序列的过程以及重复执行已学习的序列。我们将蝇蕈醇（一种GABA激动剂）注射到纹状体的不同部位，以可逆地抑制局部神经活动。在前尾状核和壳核注射后，新序列的学习变得不足，但中后壳核没有。在中后壳核注射后，以及在前尾状核/壳核注射后，不太严重的情况下，熟知序列的执行被破坏。这些结果表明，前部和后部的纹状体参与不同方面的学习顺序运动。
To study the role of the basal ganglia in learning of sequential movements, we trained two monkeys to perform a sequential button-press task (2x5 task). This task enabled us to examine the process of learning new sequences as well as the execution of well-learned sequences repeatedly. We injected muscimol (a GABA agonist) into different parts of the striatum to inactivate the local neural activity reversibly. The learning of new sequences became deficient after injections in the anterior caudate and putamen, but not the middle-posterior putamen. The execution of well-learned sequences was disrupted after injections in the middle-posterior putamen and, less severely, after injections in the anterior caudate/putamen. These results suggest that the anterior and posterior portions of the striatum participate in different aspects of learning of sequential movements.