Motherhood mitigates aging-related decrements in learning and memory an positively affects brain aging in the rat
Motherhood mitigates aging-related decrements in learning and memory an positively affects brain aging in the rat
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DOI：
10.1016/j.brainresbull.2005.03.016
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发表时间：
2005-07-30
影响因子：
3.8
通讯作者：
Kinsley, CH
中科院分区：
文献类型：
--
作者：
Gatewood, JD;Morgan, MD;Kinsley, CH
目前的工作研究了空间学习和记忆（即，在年龄匹配的未经产、经产和经产（分别为NULL、PRIM和MULT，零次、一次或两次妊娠和哺乳）中，我们在6、12、18和24个月大的时候在Morris水迷宫的旱地版本（主要任务）中进行测试，并在12、18和24个月大的时候在相同的任务中改变了诱饵井的原始位置（限制任务）。我们发现，PRIM/MULT大鼠，与年龄匹配的NULL女性相比，学习的空间任务显着更好，表现出衰减的记忆衰退，长达24个月的年龄。此外，在行为测试结束时，我们研究了这些动物的海马（CA 1和齿状回）免疫反应性淀粉样前体蛋白（APP）的水平，APP是神经变性和年龄相关的认知丧失的标志物。相对于PRIM和NULL，MULT在CA 1和DG中均显著减少APP，并且与DG中的NULL相比，PRIM具有APP减少的趋势（p < 0.06）。此外，APP水平与两项任务的表现呈负相关（即，APP越多，迷宫性能越差）。生殖，因此，其伴随的自然内分泌和产后感觉的经验，可能会促进终身学习和记忆，并可能减轻市场的神经老化，在大鼠。结合自然的激素暴露与随后的大量经验与刺激的后代可能会保留老年经产女性的大脑相对于NULL女性。(c)2005年爱思唯尔公司All rights reserved.
The current work examined spatial learning and memory (i.e., latencies to find a baited food well) in age-matched nulliparous, primiparous and multiparous (NULL, PRIM and MULT, zero, one or two pregnancies and lactations, respectively). We tested at 6, 12, 18 and 24 months of age in a dry land version of the Morris water Maze (Main task), and at 12, 18 and 24 months in the same task in which the original location of the baited well was changed (Reversal task). We show that PRIM/MULT rats, compared to the age-matched NULL females, learned the spatial tasks significantly better and exhibited attenuated memory decline, up to 24 months of age. Furthermore, at the conclusion of behavioral testing, we investigated levels of these animals' hippocampal (CAl and dentate gyrus) immunoreactive amyloid precursor protein (APP), a marker of neurodegeneration and age-related cognitive loss. MULTs had significantly reduced APP in both CAl and DG, relative to PRIMs and NULLs, and PRIMs had a trend (p < 0.06) toward a reduction in APP compared to NULLs in DG. Further, level of APP was negatively Correlated with performance in the two tasks (viz., more APP, worse maze performance). Reproduction, therefore, with its attendant natural endocrine and postpartum sensory experiences, may facilitate lifelong learning and memory, and may mitigate markets of neural aging, in the rat. Combining natural hormonal exposure with subsequent Substantial experience with stimuli from the offspring may preserve the aged parous female brain relative to that of NULL females. (c) 2005 Elsevier Inc. All rights reserved.