Midbrain dopamine neurons associated with reward processing innervate the neurogenic subventricular zone.
Midbrain dopamine neurons associated with reward processing innervate the neurogenic subventricular zone.
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DOI：
10.1523/jneurosci.1197-11.2011
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发表时间：
2011-09-14
期刊：
影响因子：
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通讯作者：
Conover JC
中科院分区：
文献类型：
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作者：
Lennington JB;Pope S;Goodheart AE;Drozdowicz L;Daniels SB;Salamone JD;Conover JC
成人神经源性脑室下区（SVZ）的协调调节是由无数的内在和外在因素完成的。神经递质多巴胺是涉及SVZ功能的一种调节分子。黑质纹状体和腹侧被盖区（VTA）中脑多巴胺神经元支配SVZ附近的区域，并且在SVZ细胞上发现多巴胺突触。在帕金森病患者和帕金森病动物模型中，SVZ内的细胞分裂在暴露于选择性去除黑质纹状体神经元的毒素后减少，这表明多巴胺对SVZ功能至关重要，黑质纹状体神经元是SVZ多巴胺的主要供应者。然而，当我们检查黑质纹状体神经元缺乏的无晶状体小鼠时，我们发现对SVZ增殖或组织没有不利影响。相反，SVZ的多巴胺神经支配追踪到腹侧被盖区腹外侧边界的神经元。同样的多巴胺能神经元群体也支配对照小鼠的SVZ。这些神经元的表征揭示了指示VTA神经元的蛋白质的表达。此外，暴露于神经毒素MPTP耗尽腹侧腹侧被盖区的神经元，导致SVZ增殖减少。总之，这些结果表明，SVZ中的多巴胺信号来源于一群中脑神经元，这些神经元通常与动机和奖励处理相关。
Coordinated regulation of the adult neurogenic subventricular zone (SVZ) is accomplished by a myriad of intrinsic and extrinsic factors. The neurotransmitter dopamine is one regulatory molecule implicated in SVZ function. Nigrostriatal and ventral tegmental area (VTA) midbrain dopamine neurons innervate regions adjacent to the SVZ, and dopamine synapses are found on SVZ cells. Cell division within the SVZ is decreased in humans with Parkinson’s disease and in animal models of Parkinson’s disease following exposure to toxins that selectively remove nigrostriatal neurons, suggesting that dopamine is critical for SVZ function and nigrostriatal neurons are the main suppliers of SVZ dopamine. However, when we examined the aphakia mouse, which is deficient in nigrostriatal neurons, we found no detrimental effect to SVZ proliferation or organization. Instead, dopamine innervation of the SVZ tracked to neurons at the ventrolateral boundary of the VTA. This same dopaminergic neuron population also innervated the SVZ of control mice. Characterization of these neurons revealed expression of proteins indicative of VTA neurons. Furthermore, exposure to the neurotoxin MPTP depleted neurons in the ventrolateral VTA and resulted in decreased SVZ proliferation. Together, these results reveal that dopamine signaling in the SVZ originates from a population of midbrain neurons more typically associated with motivational and reward processing.