The in vivo utilization of acetoacetate, D-(-)-3-hydroxybutyrate, and glucose for lipid synthesis in brain in the 18-day-old rat. Evidence for an acetyl-CoA bypass for sterol synthesis.
The in vivo utilization of acetoacetate, D-(-)-3-hydroxybutyrate, and glucose for lipid synthesis in brain in the 18-day-old rat. Evidence for an acetyl-CoA bypass for sterol synthesis.
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18 日龄大鼠脑内利用乙酰乙酸、D-(-)-3-羟基丁酸和葡萄糖进行脂质合成。
DOI：
10.1016/s0021-9258(18)50674-8
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
J. Edmond
中科院分区：
文献类型：
--
作者：
R. Webber;J. Edmond
从皮下注射的3H2O掺入~3H的脂类来判断，大鼠脑内甾醇和脂肪酸的合成在18日龄左右达到最大值。18日龄大鼠注射乙酰乙酸乙酯、D-(-)-3-羟基丁酸酯和葡萄糖后，血液中几乎没有相互转化，半衰期分别为4.7、7.4和31min。乙酰乙酸酯和3-羟基丁酸酯的14C分解/分钟与脂肪酸的比率为0.5，而葡萄糖、辛酸和乙酸酯的比率为0.23~0.30。
The synthesis of sterols and fatty acids in rat brain was maximum at about 18 days old as judged by incorporation into lipids of 3H from 3H2O given subcutaneously. There was little or no interconversion in the blood of injected acetoacetate, D-(-)-3-hydroxybutyrate and glucose in rats 18 days old and respective half-lives in blood were 4.7, 7.4 and 31 min. The ratio of disintegrations/min of 14C in sterols/g brain to that in fatty acids was 0.5 for acetoacetate and 3-hydroxybutyrate compared with 0.23 to 0.30 for glucose, octanoate and acetate.