Prenatal exposure of diclofenac sodium affects morphology but not axon number of the median nerve of rats
Prenatal exposure of diclofenac sodium affects morphology but not axon number of the median nerve of rats
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DOI：
10.5114/fn.2013.34199
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发表时间：
2013-01-01
影响因子：
2
通讯作者：
Kaplan, Suleyman
中科院分区：
文献类型：
--
作者：
Ayranci, Ebru;Altunkaynak, Berrin Zuhal;Kaplan, Suleyman
本研究探讨了 DS 暴露对大鼠产前正中神经发育的影响。将怀孕雌性大鼠分为三组：对照组、盐水组和DS组。这些动物的后代被分为 2 个亚组：4 周龄和 20 周龄。从右腿采集神经样本，并使用体视学技术评估轴突数量、轴突横截面积和髓磷脂厚度。在神经中未观察到药物依赖性宏观异常。相同年龄和性别的对照组、盐水组和 DS 组中轴突数量没有差异，其他匹配组之间的轴突数量或轴突面积没有发现性别差异。总之，产前接触双氯芬酸钠不会影响大鼠的轴突数量，但可以改变雄性和雌性正中神经的形态。
The present study examined the effect of DS exposure on median nerve development in rats during prenatal life. Pregnant female rats were divided into three groups: a control group, a saline group and a DS group. Offspring of these animals were divided into 2 subgroups: 4 weeks old and 20 weeks old. Nerve samples were taken from the right legs and evaluated using stereological techniques in terms of the axon number, axon cross-sectional area, and myelin thickness. No drug-dependent macroscopic abnormality was observed in the nerve. No differences were noted for axon number in the control, saline, and DS groups of the same age and gender No gender difference was found for axon number or axon area between the other matched groups. In conclusion, prenatal exposure to diclofenac sodium does not affect axon number in rats, but can alter the morphology of the male and female median nerve.