Physiological release of nitric oxide is dependent on the level of vascular tone.
Physiological release of nitric oxide is dependent on the level of vascular tone.
复制标题
一氧化氮的生理释放取决于血管张力的水平。
DOI：
10.1016/0014-2999(90)94204-b
复制
发表时间：
1990
影响因子：
5
通讯作者：
Chaudhuri,G
中科院分区：
文献类型：
--
作者：
Vargas,HM;Ignarro,LJ;Chaudhuri,G
在麻醉大鼠（对照组）或无交感神经紧张的大鼠中测试了NG-甲基-L-精氨酸（NMA）的加压作用。与对照组相比，脊髓或神经节阻滞的NMA反应减弱。在脊髓损伤大鼠，诱导中度或强烈的血管收缩与恒定的苯肾上腺素输注恢复或增强，分别，NMA升压反应。我们的数据表明，血管张力可能在生理上调节体内一氧化氮的释放。
The presser effect of NG-methyl-L-arginine (NMA) was tested in urethane-anesthetized rats which were untreated (control) or devoid of sympathetic tone. In contrast with controls, the NMA response was attenuated by pithing or ganglionic blockade. In pithed rats, the induction of moderate or intense vasoconstriction with constant phenylephrine infusion restored or augmented, respectively, the NMA pressor response. Our data suggest that vascular tone may physiologically regulate the release of nitric oxide in vivo.
DOI：
10.1073/pnas.85.22.8664
发表时间：
1988-11-01
影响因子：
11.1
作者：
SAKUMA, I;STUEHR, DJ;LEVI, R
通讯作者：
LEVI, R