Single whole genome sequencing analysis blazes the trail for precision medicine.
Single whole genome sequencing analysis blazes the trail for precision medicine.
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DOI：
10.1080/15384047.2022.2033058
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发表时间：
2022-12-31
影响因子：
3.6
通讯作者：
Figg WD
中科院分区：
文献类型：
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作者：
Napoli GC;Chau CH;Figg WD
As precision oncology evolves toward developing more targeted therapies, sequencing has moved to the forefront of treatment decision-making. Whole genome sequencing (WGS) has emerged as a technology capable of identifying candidates for rare and targeted treatments. Yet, because the tumor is constantly evolving during relapse and therapy resistance, the frequency with which WGS should be performed to identify potential new therapies for progressing patients remains unknown. A recent study in Nature Medicine by Van de Haar et al. observed a remarkably stable driver gene mutational profile among 250 biopsy pairs from 231 patients undergoing standard of care treatments during the biopsy interval. Their findings suggest that the actionable metastatic cancer genome is relatively stable over time and that a single WGS provides a complete view of the treatment opportunities available to most metastatic cancer patients.
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影响因子：
5.2
作者：
Makarem M;García-Pardo M;Leighl NB
通讯作者：
Leighl NB
影响因子：
82.9
作者：
van de Haar, Joris;Hoes, Louisa R.;Voest, Emile E.
通讯作者：
Voest, Emile E.
驾驶员突变的体体进化时机。
影响因子：
3.8
作者：
Gomez K;Miura S;Huuki LA;Spell BS;Townsend JP;Kumar S
通讯作者：
Kumar S
影响因子：
30.8
作者：
Pich, Oriol;Muinos, Ferran;Lopez-Bigas, Nuria
通讯作者：
Lopez-Bigas, Nuria
DOI：
10.1038/s41576-021-00370-8
发表时间：
2021-10
期刊：
Nature reviews. Genetics
影响因子：
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作者：
通讯作者：
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