LYMPHOCYTES IN THE SKIN OF PATIENTS WITH PROGRESSIVE SYSTEMIC-SCLEROSIS - QUANTIFICATION, SUBTYPING, AND CLINICAL CORRELATIONS
LYMPHOCYTES IN THE SKIN OF PATIENTS WITH PROGRESSIVE SYSTEMIC-SCLEROSIS - QUANTIFICATION, SUBTYPING, AND CLINICAL CORRELATIONS
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DOI：
10.1002/art.1780270607
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
RODNAN, GP
中科院分区：
文献类型：
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作者：
ROUMM, AD;WHITESIDE, TL;RODNAN, GP
应用单克隆抗体对进行性系统性硬化症（PSS）患者前臂真皮和血液中的单核细胞（MNC）进行定量和亚群分析。这些发现与皮肤和全身疾病的特征相关。对21例PSS患者的皮肤标本进行了T淋巴细胞及其亚群、B细胞和巨噬细胞计数。真皮MNC浸润物主要由活化的T淋巴细胞组成，平均T辅助/T抑制（T4/T8）比率为2.4 ±。1.3 SD.观察到少量B1阳性或T6阳性细胞（巨噬细胞）。皮肤或血液T4/T8比值与皮肤增厚程度之间无相关性。在组织学检查，58 115（50%）未经治疗的PSS患者有突出的真皮MNC浸润。MNC浸润程度与皮肤增厚程度（P < 0.05）和进展（P < 0.05）均呈显著相关。与PSS的其他全身性疾病特征无相关性。
Mononuclear cells (MNC) present in the dermis of the forearm and in the blood of patients with progressive systemic sclerosis (PSS) were quantified and analyzed for subsets using monoclonal antibodies. The findings were correlated with cutaneous and systemic features of the disease. Total T lymphocytes and their subsets, B cells and macrophages were enumerated in the skin samples of 21 patients with PSS. The dermal MNC infiltrates consisted mostly of activated T lymphocytes with a mean T helper/T suppressor (T4/T8) ratio of 2.4 .+-. 1.3 SD. Few B1-positive or T6-positive cells (macrophages) were observed. There was no correlation between the skin or blood T4/T8 ratios and the degree of skin thickening. On histologic examination, 58 of 115 (50%) untreated patients with PSS had prominent dermal MNC infiltration. Significant correlations between the degree of MNC infiltration and both the degree (P < 0.05) and progression (P < 0.05) of skin thickening were observed. No correlations with other systemic disease features of PSS were noted.