Increased cerebrospinal fluid YKL-40 levels are associated with disease severity of neuromyelitis optica spectrum disorders
Increased cerebrospinal fluid YKL-40 levels are associated with disease severity of neuromyelitis optica spectrum disorders
复制标题
脑脊液 YKL-40 水平升高与视神经脊髓炎谱系疾病的严重程度相关。
DOI：
10.1016/j.msard.2020.102395
复制
发表时间：
2020-10-01
影响因子：
4
通讯作者：
Yang, Li
中科院分区：
文献类型：
--
作者：
Qi, Yuan;Chou, Li-Sha;Yang, Li
背景：视神经肌萎缩症谱系障碍（NMOSD）是一种严重的免疫介导的炎症性中枢神经系统（CNS）综合征。YKL-40作为一种新的炎症标志物，在许多自身免疫性疾病和中枢神经系统疾病中得到了研究。我们的这项研究的目的是调查脑脊液（CSF）和血清YKL-40水平与NMOSD患者和疾病severity.Methods的关联：我们测量了29例NMOSD患者和21名年龄和性别匹配的对照组的CSF和血清YKL-40水平。结果：与对照组相比，NMOSD患者CSF中YKL-40水平显著升高。此外，CSF YKL-40水平与扩展残疾状态量表scores.Conclusions：YKL-40可能是NMOSD严重程度的生物标志物和NMOSD治疗的潜在靶点。
Background: Neuromyelitis optica spectrum disorders (NMOSD) is a severe immune-mediated inflammatory central nervous system (CNS) syndrome. YKL-40, as a new inflammatory marker, has been studied in many autoimmunity and CNS diseases. Our aim of this study was to investigate cerebrospinal fluid (CSF) and serum YKL-40 levels in patients with NMOSD and their association with disease severity.Methods: We measured CSF and serum YKL-40 levels in 29 patients with NMOSD and 21 age- and sex-matched controls. We analyzed the associations between CSF YKL-40 levels and the clinical variables of NMOSD.Results: Compared to controls, patients with NMOSD had significantly higher CSF YKL-40 levels. Moreover, CSF YKL-40 levels were positively correlated with the Expanded Disability Status Scale scores.Conclusions: YKL-40 could be a NMOSD severity biomarker and a potential target for NMOSD treatment.